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VER49009

Name: VER49009
Brand: TargetMol
SKU: T2268
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2268Cas No. 940289-57-6

Alias VER-49009, VER 49009, CCT0129397

VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).

VER49009

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Purity: 98.95%

Catalog No. T2268Alias VER-49009, VER 49009, CCT0129397Cas No. 940289-57-6

VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
2 mg	$77	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$176	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$497	In Stock	In Stock
100 mg	$677	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.95%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
Targets&IC50	HSP90:25 nM
In vitro	In the human ovarian tumor model, intraperitoneal injection of VER-49009 (4 mg/kg) can induce the dissociation of HSP90 and ERBB2. In athymic mice, intravenous injection of VER-49009 (20 mg/kg) demonstrates efficacy.
In vivo	VER-49009 can induce the dissociation of HSP72 and HSP27 from their binding proteins, leading to cell cycle arrest. In recombinant yeast Hsp90 protein (IC50 = 167 nM), VER-49009 inhibits the endogenous ATPase activity. During the treatment of liver fibrosis, VER-49009 induces the accumulation of hepatic stellate cells (CFSC) in the G2 phase, inhibiting cell growth.
Kinase Assay	Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe.
Cell Research	Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference)
Synonyms	VER-49009, VER 49009, CCT0129397

Chemical Properties

Molecular Weight	387.82
Formula	C₁₉H₁₈ClN₃O₄
Cas No.	940289-57-6
Smiles	c1(c(cc(c(c1)c1c(c([nH]n1)C(=O)NCC)c1ccc(cc1)OC)O)O)Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (183.07 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5785 mL	12.8926 mL	25.7852 mL	128.9258 mL
5 mM	0.5157 mL	2.5785 mL	5.1570 mL	25.7852 mL
10 mM	0.2579 mL	1.2893 mL	2.5785 mL	12.8926 mL
20 mM	0.1289 mL	0.6446 mL	1.2893 mL	6.4463 mL
50 mM	0.0516 mL	0.2579 mL	0.5157 mL	2.5785 mL
100 mM	0.0258 mL	0.1289 mL	0.2579 mL	1.2893 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc