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MK-8353

Name: MK-8353
Brand: TargetMol
SKU: T12069
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12069Cas No. 1184173-73-6

Alias SCH900353

MK-8353 (SCH900353) is a potent, selective, and orally available inhibitor of ERK1/2 with IC50 values of 23.0 nM and 8.8 nM, respectively.

MK-8353

🥰Excellent

Purity: 97.19%

Catalog No. T12069Alias SCH900353Cas No. 1184173-73-6

MK-8353 (SCH900353) is a potent, selective, and orally available inhibitor of ERK1/2 with IC50 values of 23.0 nM and 8.8 nM, respectively.

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$158	In Stock
10 mg	$286	In Stock
25 mg	$652	In Stock
50 mg	$987	In Stock
100 mg	$1,530	In Stock
1 mL x 10 mM (in DMSO)	$242	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:97.19%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MK-8353 (SCH900353) is a potent, selective, and orally available inhibitor of ERK1/2 with IC50 values of 23.0 nM and 8.8 nM, respectively.
Targets&IC50	ERK1:23 nM, ERK2:8.8 nM
In vitro	MK-8353 is a potent, selective, and orally available ERK1/2 inhibitor with IC50 values of 23.0 nM and 8.8 nM, respectively; it exhibits antitumor activity.
In vivo	MK-8353 causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells[1].
Synonyms	SCH900353

Chemical Properties

Molecular Weight	691.84
Formula	C₃₇H₄₁N₉O₃S
Cas No.	1184173-73-6
Smiles	CS[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncn(C)n2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(OC(C)C)nc3)c2c1
Relative Density.	1.36 g/cm3 (Predicted)
Color	Orange
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (180.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4454 mL	7.2271 mL	14.4542 mL	72.2710 mL
5 mM	0.2891 mL	1.4454 mL	2.8908 mL	14.4542 mL
10 mM	0.1445 mL	0.7227 mL	1.4454 mL	7.2271 mL
20 mM	0.0723 mL	0.3614 mL	0.7227 mL	3.6136 mL
50 mM	0.0289 mL	0.1445 mL	0.2891 mL	1.4454 mL
100 mM	0.0145 mL	0.0723 mL	0.1445 mL	0.7227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc