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Setrobuvir

Name: Setrobuvir
Brand: TargetMol
SKU: T28762
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28762Cas No. 1071517-39-9

Alias RO-5466731, RG-7790, RG7790, ANA-598, ANA598

Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.

Setrobuvir

🥰Excellent

Purity: 98.92%

Catalog No. T28762Alias RO-5466731, RG-7790, RG7790, ANA-598, ANA598Cas No. 1071517-39-9

Pack Size	Price	Availability
1 mg	$240	In Stock
5 mg	$600	In Stock
10 mg	$855	In Stock
25 mg	$1,280	In Stock
50 mg	$1,750	In Stock
100 mg	$2,360	In Stock
500 mg	$4,730	In Stock
1 mL x 10 mM (in DMSO)	$776	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.92%

ee:96.18%

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COA FNMR HNMR LCMS CSFC

Product Introduction

Bioactivity

Description	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.
Targets&IC50	RNA synthesis and primer extension:4~5 nM, HCV NS5B 1a:52 nM (EC50), HCV NS5B 1b:3 nM (EC50)
In vivo	Setrobuvir (200, 400, and 800 mg) BID were -2.1, -2.2, and -2.9 log10 IU/mL, respectively (vs ≤0.1 log10 IU/mL with placebo).[3]
Synonyms	RO-5466731, RG-7790, RG7790, ANA-598, ANA598

Chemical Properties

Molecular Weight	560.62
Formula	C₂₅H₂₅FN₄O₆S₂
Cas No.	1071517-39-9
Smiles	C(N1[C@@]2([C@@]([C@@]3(C[C@]2(CC3)[H])[H])(C(O)=C(C1=O)C=4NC=5C(S(=O)(=O)N4)=CC(NS(C)(=O)=O)=CC5)[H])[H])C6=CC=C(F)C=C6
Relative Density.	1.72 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (450.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7837 mL	8.9187 mL	17.8374 mL	89.1870 mL
5 mM	0.3567 mL	1.7837 mL	3.5675 mL	17.8374 mL
10 mM	0.1784 mL	0.8919 mL	1.7837 mL	8.9187 mL
20 mM	0.0892 mL	0.4459 mL	0.8919 mL	4.4593 mL
50 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7837 mL
100 mM	0.0178 mL	0.0892 mL	0.1784 mL	0.8919 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc