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Setrobuvir

Name: Setrobuvir
Brand: TargetMol
SKU: T28762
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28762Cas No. 1071517-39-9

Alias RO-5466731, RG-7790, RG7790, ANA-598, ANA598

Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.

Setrobuvir

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Purity: 99.97%

Catalog No. T28762Alias RO-5466731, RG-7790, RG7790, ANA-598, ANA598Cas No. 1071517-39-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$240	In Stock	In Stock
5 mg	$600	In Stock	In Stock
10 mg	$855	In Stock	In Stock
25 mg	$1,280	In Stock	In Stock
50 mg	$1,750	-	In Stock
100 mg	$2,360	-	In Stock
500 mg	$4,730	-	In Stock
1 mL x 10 mM (in DMSO)	$776	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

ee:100%

Appearance:Solid

Color:White to Yellow

Resource Download

COA CSFC FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.
Targets&IC50	RNA synthesis and primer extension:4~5 nM, HCV NS5B 1b:3 nM (EC50), HCV NS5B 1a:52 nM (EC50)
In vivo	Setrobuvir (200, 400, and 800 mg) BID were -2.1, -2.2, and -2.9 log10 IU/mL, respectively (vs ≤0.1 log10 IU/mL with placebo).[3]
Synonyms	RO-5466731, RG-7790, RG7790, ANA-598, ANA598

Chemical Properties

Molecular Weight	560.62
Formula	C₂₅H₂₅FN₄O₆S₂
Cas No.	1071517-39-9
Smiles	C(N1[C@@]2([C@@]([C@@]3(C[C@]2(CC3)[H])[H])(C(O)=C(C1=O)C=4NC=5C(S(=O)(=O)N4)=CC(NS(C)(=O)=O)=CC5)[H])[H])C6=CC=C(F)C=C6
Relative Density.	1.72 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (450.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7837 mL	8.9187 mL	17.8374 mL	89.1870 mL
5 mM	0.3567 mL	1.7837 mL	3.5675 mL	17.8374 mL
10 mM	0.1784 mL	0.8919 mL	1.7837 mL	8.9187 mL
20 mM	0.0892 mL	0.4459 mL	0.8919 mL	4.4593 mL
50 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7837 mL
100 mM	0.0178 mL	0.0892 mL	0.1784 mL	0.8919 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc