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Anti-XRCC1 Polyclonal Antibody
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Catalog No. TMAB-14217
Anti-XRCC1 Polyclonal Antibody is a Rabbit antibody targeting XRCC1. Anti-XRCC1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-XRCC1 Polyclonal Antibody
Anti-XRCC1 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-14217
Anti-XRCC1 Polyclonal Antibody is a Rabbit antibody targeting XRCC1. Anti-XRCC1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-XRCC1 Polyclonal Antibody is a Rabbit antibody targeting XRCC1. Anti-XRCC1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-XRCC1 Polyclonal Antibody, Unconjugated (TMAB-14217) 1: 200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Accumulates at sites of DNA damage. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. In testis XRCC1 is expressed at high levels. |
| Immunogen | KLH conjugated synthetic peptide: human XRCC1 |
| Antigen Species | Human |
| Gene Name | XRCC1 |
| Gene ID | |
| Protein Name | DNA repair protein XRCC1 |
| Uniprot ID | |
| Function | Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. |
| Molecular Weight | Theoretical: 69 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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