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Anti-CD31 Polyclonal Antibody 4
😃Good
Catalog No. TMAB-03942
Anti-CD31 Polyclonal Antibody 4 is a Rabbit antibody targeting CD31. Anti-CD31 Polyclonal Antibody 4 can be used in IHC-P,IHC-Fr,IF.
Anti-CD31 Polyclonal Antibody 4
Anti-CD31 Polyclonal Antibody 4
😃Good
Catalog No. TMAB-03942
Anti-CD31 Polyclonal Antibody 4 is a Rabbit antibody targeting CD31. Anti-CD31 Polyclonal Antibody 4 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CD31 Polyclonal Antibody 4 is a Rabbit antibody targeting CD31. Anti-CD31 Polyclonal Antibody 4 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:200-500; IHC-Fr: 1:200-500; IF: 1:200-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. |
| Tissue Specificity | Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369).Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308).Expressed on neutrophils (at protein level) (PubMed:17580308).Isoform Long predominates in all tissues examined (PubMed:12433657).Isoform Delta12 is detected only in trachea (PubMed:12433657).Isoform Delta14-15 is only detected in lung (PubMed:12433657).Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657).Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010] |
| Immunogen | KLH conjugated synthetic peptide: mouse CD31 |
| Antigen Species | Mouse |
| Gene Name | PECAM1 |
| Gene ID | |
| Protein Name | Platelet endothelial cell adhesion molecule |
| Uniprot ID | |
| Function | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).Induces susceptibility to atherosclerosis (By similarity). |
| Molecular Weight | Theoretical: 78 kDa. |
| Color | Transparent |
| Appearance | Liquid |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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