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LDN-209929 dihydrochloride
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Catalog No. T62011Cas No. 1784281-97-5
Alias LDN209929 dihydrochloride, LDN 209929 dihydrochloride
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor with an IC50 value of 55 nM and approximately 180-fold selectivity over DYRK2 (IC50 = 9.9 μM), LDN-209929 represents an optimized analogue of LDN-192960 that is applied in cell cycle and mitotic regulation research to investigate haspin-dependent phosphorylation events.
LDN-209929 dihydrochloride
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Purity: 98.14%
Catalog No. T62011Alias LDN209929 dihydrochloride, LDN 209929 dihydrochlorideCas No. 1784281-97-5
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor with an IC50 value of 55 nM and approximately 180-fold selectivity over DYRK2 (IC50 = 9.9 μM), LDN-209929 represents an optimized analogue of LDN-192960 that is applied in cell cycle and mitotic regulation research to investigate haspin-dependent phosphorylation events.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $55 | - | In Stock | |
| 5 mg | $129 | - | In Stock | |
| 10 mg | $213 | - | In Stock | |
| 25 mg | $455 | - | In Stock | |
| 50 mg | $787 | - | In Stock | |
| 100 mg | $1,280 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.14%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor with an IC50 value of 55 nM and approximately 180-fold selectivity over DYRK2 (IC50 = 9.9 μM), LDN-209929 represents an optimized analogue of LDN-192960 that is applied in cell cycle and mitotic regulation research to investigate haspin-dependent phosphorylation events. |
| In vitro | In kinase inhibition assays, LDN-209929 dihydrochloride functioned as a potent inhibitor of Haspin and DYRK2. It effectively disrupted the phosphorylation of Histone H3 at Threonine 3 (H3T3) and blocked the autophosphorylation of the critical tyrosine residue in the activation loop of DYRK2 [1]. |
| Synonyms | LDN209929 dihydrochloride, LDN 209929 dihydrochloride |
| Molecular Weight | 405.77 |
| Formula | C17H19Cl3N2OS |
| Cas No. | 1784281-97-5 |
| Smiles | ClC1=CC2=C(N=C3C=CC(OC)=CC3=C2SCCCN)C=C1.Cl.Cl |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (61.61 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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