Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDN-209929 dihydrochloride is a potent and selective inhibitor of haspin kinase (IC50= 55 nM). LDN-209929 dihydrochloride shows180-fold selectivity verses DYRK2 (IC50= 9.9 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | 6-8 weeks | $ 788.00 | |
100 mg | 6-8 weeks | $ 1,280.00 |
Description | LDN-209929 dihydrochloride is a potent and selective inhibitor of haspin kinase (IC50= 55 nM). LDN-209929 dihydrochloride shows180-fold selectivity verses DYRK2 (IC50= 9.9 μM). |
In vitro | Haspin, a Haploid Germ Cell-Specific Nuclear Protein Kinase, is a serine/threonine kinase, expressed across various tissues, including testis, bone marrow, thymus, and spleen. It is crucial for mitotic processes, especially for phosphorylating histone H3 at Thr-3 (H3T3) during G2/early prophase. Its activity peaks in prometaphase/metaphase and decreases by anaphase [1]. DYRKs, part of the CMGC family of ePKs, are categorized into class 1 (DYRK1A and 1B) and class 2 (DYRK2, 3, and 4) kinases. Their functionality relies on the autophosphorylation of a vital activation loop tyrosine during protein synthesis [1]. |
Molecular Weight | 405.77 |
Formula | C17H19Cl3N2OS |
CAS No. | 1784281-97-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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LDN-209929 dihydrochloride 1784281-97-5 inhibitor inhibit