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LDN-209929 dihydrochloride
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Catalog No. T62011Cas No. 1784281-97-5
Alias LDN209929 dihydrochloride, LDN 209929 dihydrochloride
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor with an IC50 value of 55 nM and approximately 180-fold selectivity over DYRK2 (IC50 = 9.9 μM), LDN-209929 represents an optimized analogue of LDN-192960 that is applied in cell cycle and mitotic regulation research to investigate haspin-dependent phosphorylation events.
LDN-209929 dihydrochloride
😃Good
Catalog No. T62011Alias LDN209929 dihydrochloride, LDN 209929 dihydrochlorideCas No. 1784281-97-5
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor with an IC50 value of 55 nM and approximately 180-fold selectivity over DYRK2 (IC50 = 9.9 μM), LDN-209929 represents an optimized analogue of LDN-192960 that is applied in cell cycle and mitotic regulation research to investigate haspin-dependent phosphorylation events.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $55 | - | In Stock | |
| 5 mg | $129 | - | In Stock | |
| 10 mg | $213 | - | In Stock | |
| 25 mg | $455 | - | In Stock | |
| 50 mg | $787 | - | In Stock | |
| 100 mg | $1,280 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor with an IC50 value of 55 nM and approximately 180-fold selectivity over DYRK2 (IC50 = 9.9 μM), LDN-209929 represents an optimized analogue of LDN-192960 that is applied in cell cycle and mitotic regulation research to investigate haspin-dependent phosphorylation events. |
| In vitro | In kinase inhibition assays, LDN-209929 dihydrochloride functioned as a potent inhibitor of Haspin and DYRK2. It effectively disrupted the phosphorylation of Histone H3 at Threonine 3 (H3T3) and blocked the autophosphorylation of the critical tyrosine residue in the activation loop of DYRK2 [1]. |
| Synonyms | LDN209929 dihydrochloride, LDN 209929 dihydrochloride |
| Molecular Weight | 405.77 |
| Formula | C17H19Cl3N2OS |
| Cas No. | 1784281-97-5 |
| Smiles | ClC1=CC2=C(N=C3C=CC(OC)=CC3=C2SCCCN)C=C1.Cl.Cl |
| Color | Orange |
| Appearance | Solid |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (61.61 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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