Nociceptin (1-13), amide

Name: Nociceptin (1-13), amide
Brand: TargetMol
SKU: TP1793
Rating: 4.5 (1 reviews)

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Catalog No. TP1793Cas No. 178064-02-3

Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist, exhibiting a pEC50 of 7.9 in mouse vas deferens and a Ki of 0.75 nM for rat forebrain membrane binding.

Nociceptin (1-13), amide

😃Good

Catalog No. TP1793Cas No. 178064-02-3

Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist, exhibiting a pEC50 of 7.9 in mouse vas deferens and a Ki of 0.75 nM for rat forebrain membrane binding.

Pack Size	Price	Availability
5 mg	$100	Backorder
10 mg	$152	Backorder
25 mg	$229	Backorder
50 mg	$342	Backorder

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Bioactivity

Description

Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist, exhibiting a pEC50 of 7.9 in mouse vas deferens and a Ki of 0.75 nM for rat forebrain membrane binding.

Chemical Properties

Molecular Weight	1381.59
Formula	C₆₁H₁₀₀N₂₂O₁₅
Cas No.	178064-02-3
Smiles	C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O
Relative Density.	1.45 g/cm3 (Predicted)
Sequence	{Phe}{Gly}{Gly}{Phe}{Thr}{Gly}{Ala}{Arg}{Lys}{Ser}{Ala}{Arg}{Lys}-NH2
Sequence Short	FGGFTGARKSARK-NH2

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keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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