Anti-CTNNA1 Antibody (2G303) is a Rabbit antibody targeting CTNNA1. Anti-CTNNA1 Antibody (2G303) can be used in IF, IHC-Fr, IHC-P, IP, WB.

IgG

2G303

Human,Mouse,Rat

IF=1:50-200; IHC-Fr=1:50-200; IHC-P=1:50-200; IP=1:20-50; WB=1:500-5000

Monoclonal

A synthesized peptide: human alpha Catenin

Human

CTNNA1

Catenin alpha-1

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.