Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMG-11 quarterhydrate is a potent and selective antagonist of human TLR2 which inhibits both TLR2/1 and TLR2/6 signaling with low cytotoxicity. The IC 50 s of MMG-11 quarterhydrate for Pam 3 CSK 4 -induced hTLR2/1 and for Pam 2 CSK 4 -induced hTLR2/6 responses is 1.7 μM and 5.7 μM, respectively[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | 10-14 weeks | $ 1,220.00 | |
200 mg | 10-14 weeks | $ 1,850.00 |
Description | MMG-11 quarterhydrate is a potent and selective antagonist of human TLR2 which inhibits both TLR2/1 and TLR2/6 signaling with low cytotoxicity. The IC 50 s of MMG-11 quarterhydrate for Pam 3 CSK 4 -induced hTLR2/1 and for Pam 2 CSK 4 -induced hTLR2/6 responses is 1.7 μM and 5.7 μM, respectively[1]. |
In vitro | MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 μM) shows no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs) [1]. Cell Cytotoxicity Assay [1] Cell Line: PBMCs Concentration: 0.01, 1, 10, 100 μM Incubation Time: Result: Showed no cytotoxic effects up to 100 μM. |
Molecular Weight | 310.78 |
Formula | C15H16O8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MMG-11 quarterhydrate inhibitor inhibit