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IL-4-inhibitor-1

🥰Excellent
Catalog No. T36527Cas No. 1332184-63-0

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

IL-4-inhibitor-1

IL-4-inhibitor-1

🥰Excellent
Purity: 100%
Catalog No. T36527Cas No. 1332184-63-0
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$185In Stock
10 mg$347In Stock
25 mg$589In Stock
50 mg$842In Stock
100 mg$1,160In Stock
1 mL x 10 mM (in DMSO)$148In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:100%
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Product Introduction

Bioactivity
Description
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
Targets&IC50
IL-4:1.81 µM (EC50)
In vitro
IL-4-inhibitor-1 exhibits functional disruption of type II IL-4 binding in a cellular context and dose-dependent reduces pSTAT-6 levels (EC50 = 3.1 µM)[1].
Chemical Properties
Molecular Weight321.31
FormulaC18H12FN3O2
Cas No.1332184-63-0
SmilesNc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1
Relative Density.1.50 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 10 mg/mL (31.12 mM), Sonication is recommended.
DMF: 27 mg/mL (84.03 mM), Sonication is recommended.
DMSO:PBS (pH 7.2) (1:5): 0.1 mg/mL (0.31 mM), Sonication is recommended.
DMSO: 50 mg/mL (155.61 mM), Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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