Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 185.00 | |
10 mg | In stock | $ 347.00 | |
25 mg | In stock | $ 589.00 | |
50 mg | In stock | $ 842.00 | |
100 mg | In stock | $ 1,160.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway. |
Targets&IC50 | IL-4:1.81 µM (EC50) |
In vitro | IL-4-inhibitor-1 exhibits functional disruption of type II IL-4 binding in a cellular context and dose-dependent reduces pSTAT-6 levels (EC50 = 3.1 µM)[1]. |
Molecular Weight | 321.31 |
Formula | C18H12FN3O2 |
CAS No. | 1332184-63-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL
DMF: 27.0 mg/mL (84.1 mM)
DMSO:PBS (pH 7.2) (1:5): 0.1 mg/mL
DMSO: 27.0 mg/mL (84.1 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IL-4-inhibitor-1 1332184-63-0 Immunology/Inflammation IL Receptor IL4inhibitor1 IL 4 inhibitor 1 inhibitor inhibit