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CDDO-3P-Im

Name: CDDO-3P-Im
Brand: TargetMol
SKU: T13603
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13603Cas No. 1883650-95-0

CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.

CDDO-3P-Im

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Purity: 97.72%

Catalog No. T13603Cas No. 1883650-95-0

CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$558	In Stock	In Stock
50 mg	$788	In Stock	In Stock
100 mg	$1,120	In Stock	In Stock
200 mg	$1,480	-	In Stock
1 mL x 10 mM (in DMSO)	$278	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.72%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.
In vitro	CDDO-3P-Im (30 nM) induces differentiation of U937 cells. In RAW264.7 cells, CDDO-3P-Im suppresses NO production (IC50 = 4.3 nM)[1].
In vivo	CDDO-3P-Im reduces the size and the severity of the lung tumors in mouse lung cancer models. In A/J mice, CDDO-3P-Im (50-200 mg/kg; diet) decreases the number, size, and severity of tumors. CDDO-3P-Im significantly elevates heme oxygenase-1 and quinone reductase mRNA and protein levels in various mouse tissues[1].

Chemical Properties

Molecular Weight	618.81
Formula	C₃₉H₄₆N₄O₃
Cas No.	1883650-95-0
Smiles	[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]3(C)C=C(C#N)C(=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(=O)n1cnc(c1)-c1cccnc1
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (363.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6160 mL	8.0800 mL	16.1600 mL	80.8002 mL
5 mM	0.3232 mL	1.6160 mL	3.2320 mL	16.1600 mL
10 mM	0.1616 mL	0.8080 mL	1.6160 mL	8.0800 mL
20 mM	0.0808 mL	0.4040 mL	0.8080 mL	4.0400 mL
50 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6160 mL
100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.8080 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc