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Abacavir

Name: Abacavir
Brand: TargetMol
SKU: T1267
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1267Cas No. 136470-78-5

Alias Ziagen, Epzicom

Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.

Abacavir

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Purity: 99.81%

Catalog No. T1267Alias Ziagen, EpzicomCas No. 136470-78-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$47	In Stock	In Stock
25 mg	$70	In Stock	In Stock
50 mg	$92	In Stock	In Stock
100 mg	$117	In Stock	In Stock
200 mg	$147	In Stock	In Stock
500 mg	$246	In Stock	In Stock
1 g	$363	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Abacavir AI Summary

Abacavir exhibits broad antiviral activity and cytostatic properties across various viral strains and cell lines. It demonstrates significant efficacy against HIV-1 Reverse Transcriptase, including both wild type and M184V mutant with EC50 values of 5300.0 nM and 15500.0 nM, respectively. Its activity against HIV-1 replication in CEM cells is notable, with an EC50 of 1600.0 nM and a cytotoxicity CC50 of 83000.0 nM. Furthermore, it shows antiviral activity against HIV-2 with EC50 values ranging from 3000.0 nM to 7300.0 nM, and herpes simplex virus types 1 and 2. In HBV mutants, Abacavir achieves 80.0% and 72.0% inhibition against M204I and L180M/M204V mutants, respectively, with an overall EC50 of 3400.0 nM. Additionally, it is potent against multidrug-resistant HIV-1 strains, demonstrated by fold change values ranging from 1.4 to 29.0 relative to wild type. The compound also shows high oral bioavailability at 86.0% in humans, suggesting effective systemic uptake when administered orally. Abacavir displays inhibitory effects on different enzymes and receptors, including Histone Lysine Methyltransferase G9a, and exhibits liver toxicity as indicated by a high DILI severity score of 8.0. It shows relatively low clearance rates and short half-life in humans. The compound's pharmacokinetic profile reveals gender-specific differences in drug metabolism. Despite its antiviral properties, Abacavir has a moderate bioactivity profile, with some cytotoxicity against various human cell lines and a non-significant inhibition of P-gp. It has limited binding affinity for human serum albumin and shows potential hepatotoxicity based on liver function tests. Additionally, Abacavir has an IC50 value greater than 20000.0 nM for SARS-CoV-2, indicating low potency in this context. Overall, these characteristics underscore its potential for further development in antiviral therapies, albeit with considerations for associated hepatotoxic risks..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.
Synonyms	Ziagen, Epzicom

Chemical Properties

Molecular Weight	286.33
Formula	C₁₄H₁₈N₆O
Cas No.	136470-78-5
Smiles	N(C1=C2C(N(C=N2)[C@@H]3C[C@H](CO)C=C3)=NC(N)=N1)C4CC4
Relative Density.	1.70 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (873.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4925 mL	17.4624 mL	34.9247 mL	174.6237 mL
5 mM	0.6985 mL	3.4925 mL	6.9849 mL	34.9247 mL
10 mM	0.3492 mL	1.7462 mL	3.4925 mL	17.4624 mL
20 mM	0.1746 mL	0.8731 mL	1.7462 mL	8.7312 mL
50 mM	0.0698 mL	0.3492 mL	0.6985 mL	3.4925 mL
100 mM	0.0349 mL	0.1746 mL	0.3492 mL	1.7462 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc