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CBL0137

Name: CBL0137
Brand: TargetMol
SKU: T4126
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4126Cas No. 1197996-80-7

Alias Curaxin 137, CBLC137

CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.

CBL0137

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Purity: 99.68%

Catalog No. T4126Alias Curaxin 137, CBLC137Cas No. 1197996-80-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$135	In Stock	In Stock
10 mg	$217	In Stock	In Stock
25 mg	$436	In Stock	In Stock
50 mg	$591	-	In Stock
100 mg	$787	-	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

CBL0137 AI Summary

CBL0137 is a molecule that exhibits various bioactivities related to DNA binding and inhibition of DNA methylation mediated by the murine DNMT3A catalytic domain. It shows significant binding affinity to different 30-mer duplex DNA sequences with varying dissociation constants (Kd) and demonstrates the ability to inhibit the DNA methylation process catalyzed by DNMT3A, as indicated by its IC50 values. Additionally, it interacts with the murine DNMT3A catalytic domain, forming enzyme-DNA complexes. Overall, CBL0137 displays potent bioactivities in the context of DNA binding and inhibition of DNA methylation processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.
Targets&IC50	p53:0.37 μM (EC50), NF-κB:0.47 μM (EC50)
Synonyms	Curaxin 137, CBLC137

Chemical Properties

Molecular Weight	336.43
Formula	C₂₁H₂₄N₂O₂
Cas No.	1197996-80-7
Smiles	C(CNC(C)C)N1C=2C(C=3C1=CC=C(C(C)=O)C3)=CC(C(C)=O)=CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (74.31 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9724 mL	14.8619 mL	29.7239 mL	148.6193 mL
5 mM	0.5945 mL	2.9724 mL	5.9448 mL	29.7239 mL
10 mM	0.2972 mL	1.4862 mL	2.9724 mL	14.8619 mL
20 mM	0.1486 mL	0.7431 mL	1.4862 mL	7.4310 mL
50 mM	0.0594 mL	0.2972 mL	0.5945 mL	2.9724 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc