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(-)-Epigallocatechin-3-O-(4-O-methyl)gallate (Synonyms: EGCG4′′Me)

Name: (-)-Epigallocatechin-3-O-(4-O-methyl)gallate
Brand: TargetMol
SKU: TN13196
Rating: 4.5 (1 reviews)

Catalog No. TN13196 Copy Product Info

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(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. This compound can inhibit histamine release and possesses anti-inflammatory and antiallergic properties. It is useful in immunology and inflammation research, such as in studies of type I hypersensitivity reactions.

(-)-Epigallocatechin-3-O-(4-O-methyl)gallate

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Catalog No. TN13196

Synonyms EGCG4′′Me

(-)-Epigallocatechin-3-O-
(4-O-methyl)gallate

Cas No. 224434-07-5

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. This compound can inhibit histamine release and possesses anti-inflammatory and antiallergic properties. It is useful in immunology and inflammation research, such as in studies of type I hypersensitivity reactions.
In vitro	(-)-Epigallocatechin-3-O-(4-O-methyl)gallate, also known as Compound C-2, at a concentration of 50 μg/mL, inhibits histamine release from IgE/antigen-activated mouse mast cells by 45%. When used at a concentration of 500 μg/mL for 15 minutes, it demonstrates excellent plasma stability with a degradation rate of 10%.
In vivo	Compound C-2, (-)-Epigallocatechin-3-O-(4-O-methyl)gallate, administered orally at doses of 5-50 mg/kg, can significantly inhibit Type I allergic reactions in mice sensitized with ovalbumin and incomplete Freund's adjuvant.
Synonyms	EGCG4′′Me

Chemical Properties

Molecular Weight	472.4
Formula	C₂₃H₂₀O₁₁
Cas No.	224434-07-5
Smiles	O(C(=O)C1=CC(O)=C(OC)C(O)=C1)[C@H]2[C@H](OC=3C(C2)=C(O)C=C(O)C3)C4=CC(O)=C(O)C(O)=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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