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SCH-37370
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Catalog No. T19686Cas No. 117796-52-8
SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM).
SCH-37370
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Purity: 99.07%
Catalog No. T19686Cas No. 117796-52-8
SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | In Stock | In Stock | |
| 5 mg | $82 | In Stock | In Stock | |
| 10 mg | $117 | In Stock | In Stock | |
| 25 mg | $206 | In Stock | In Stock | |
| 50 mg | $306 | In Stock | In Stock | |
| 100 mg | $413 | In Stock | In Stock | |
| 200 mg | $548 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $83 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.07%
Appearance:Solid
Color:White
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Product Introduction
SCH-37370 AI Summary
SCH-37370 is a versatile bioactive substance known for its multifaceted pharmacological properties. It inhibits farnesyltransferase with an IC50 of 27000.0 nM, suggesting potential therapeutic applications related to farnesyltransferase activity. Additionally, SCH-37370 effectively inhibits platelet aggregation induced by Platelet-Activating Factor (PAF) in human platelet-rich plasma with an IC50 of 610.0 nM. It exhibits binding affinity to the histamine H1 receptor with a Ki value of 320.0 nM, displacing [3H]-pyrilamine in rat brain membranes. The compound also shows significant inhibition of guinea pig bronchospasm at a peroral dose of 10 mg/kg after 2 hours, followed by an IV challenge with PAF or histamine. It demonstrates antiviral activity against SARS-CoV-2, with an IC50 greater than 19952.62 nM in VERO-6 cells, although the potency is less prominent in this context. SCH-37370’s diverse bioactivities encompass antiallergic properties, CNS effects, and potential endotoxin-inhibitory effects, making it a compound of interest in various pharmacological research domains..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM). |
| Targets&IC50 | PAF:0.6 mM |
| Molecular Weight | 352.86 |
| Formula | C21H21ClN2O |
| Cas No. | 117796-52-8 |
| Smiles | ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(C)=O)CC4)=CC1 |
| Relative Density. | 1.257g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (85.02 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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