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Estrogen/progestogen Receptor

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors.The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.

  • Tamoxifen
    T690610540-29-1
    • $39
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  • 4-Hydroxytamoxifen
    T442068047-06-3
    4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer research.
    • $64
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    TargetMol | Citations Cited
  • Medroxyprogesterone Acetate
    T126171-58-9
    Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
    • $30
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  • Allura Red AC
    TN137025956-17-6
    Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.
    • $50
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  • Natamycin
    T07097681-93-8
    Natamycin (Pimaricin) is a Polyene Antimicrobial.
    • $38
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    TargetMol | Citations Cited
  • Fulvestrant
    T2146129453-61-8
    Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.
    • $42
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  • Ulipristal acetate
    T2527126784-99-4
    Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception.
    • $45
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  • Estradiol
    T104850-28-2
    Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).
    • $30
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    TargetMol | Citations Cited
  • Chlorotrianisene
    T2569569-57-3
    Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.
    • $37
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  • Mifepristone
    T110284371-65-3
    Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
    • $37
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  • Astragaloside IV
    T297384687-43-4
    Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
    • $32
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  • Levonorgestrel
    T1263797-63-7
    Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
    • $42
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  • Ethisterone
    T0301434-03-7
    Ethisterone (17α-Ethynyltestosterone) is a progestogen hormone.
    • $50
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  • Kaempferol
    T2177520-18-3
    Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
    • $46
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  • Panomifene TFA
    T33876L1 In house
    Panomifene TFA(GYKl13504 TFA) is a small molecule antagonist of ERs with anticancer activity that can be used to study breast cancer and musculoskeletal diseases.
    • $195
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  • Zindoxifene
    T2364786111-26-4In house
    Zindoxifene (D 16726) is an anti-estrogenic compound with antitumor activity that can be used in studies of breast and prostate cancer.
    • $293 TargetMol
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  • Serba-2
    T9799533884-08-1In house
    Serba-2 is an agonist of benzopyran selective estrogen receptor beta.
    • $148
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  • Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel-
    T9800533883-77-1In house
    Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel- is an estrogen receptor beta (ERβ) agonist.
    • $148
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  • SNG-1153
    T53481446712-19-1
    SNG-1153 is a estrogen receptor ER-alpha36 modulator.
    • $37
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  • 4,4'-Iminodiphenol
    T135071752-24-5
    4,4'-Iminodiphenol (Leucoindophenol) is an inactive estrogen receptor ligand with a diphenylamine backbone.
    • $41
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  • OBHSA
    T777241404508-27-5
    OBHSA(Oxabicycloheptane sulfonamide) is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer.
    • $195
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  • Indazole-Cl
    T25534848142-62-1In house
    Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).
    • $195
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  • XR 5944
    T35187343247-32-5
    XR 5944 is an antitumor compound that targets DNA, is a topoisomerase inhibitor, inhibits ER activity, and can be used to study colon and lung cancer.
    • $293
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  • Estrogen receptor antagonist 8
    T786462889370-92-5In house
    Estrogen receptor antagonist 8 acts as an estrogen receptor (ER) antagonist with anti-uterine activity and potential anti-tumorigenic activity and can be used to study ovarian dysfunction.
    • $293 TargetMol
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  • Erteberel
    T6306533884-09-2In house
    Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
    • $156
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  • LY88074
    T11915177744-96-6In house
    LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation.
    • $197
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  • Prinaberel
    TQ0149524684-52-4In house
    Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
    • $66
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  • ERRα antagonist-1
    T112301072145-33-5In house
    ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, displaying IC50 values of 170 nM and 180 nM, respectively. Notably, ERRα antagonist-1 does not interfere with the interactions involving ERRβ or ERRγ and the PGC-1α and PGC-1β coactivators. Furthermore, it does not affect the interaction between either ERα or ERβ and PGC-1α or SRC-1.
    • $35
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  • Clomiphene citrate
    T119350-41-9
    Clomiphene citrate (NSC 35770) is a selective estrogen receptor modulator.
    • $45
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    TargetMol | Citations Cited
  • Medroxyprogesterone
    T5040520-85-4
    Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
    • $33
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    TargetMol | Citations Cited
  • Liquiritigenin
    T3325578-86-9
    Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
    • $48
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  • DPN
    T76441428-67-7
    DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
    • $32
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  • Epiandrosterone
    T2195481-29-8
    Epiandrosterone (EpiA) is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
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    • Raloxifene hydrochloride
      T154982640-04-8
      Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
      • $38
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    • Ethynodiol diacetate
      T0996297-76-7
      Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
      • $58
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    • Brilanestrant
      T51181365888-06-7
      Brilanestrant (GDC-0810) is a selective estrogen receptor degrader (IC50: 0.7 nM).
      • $48
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      TargetMol | Citations Cited
    • (E/Z)-4-Hydroxytamoxifen
      T674368392-35-8
      (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
      • $47
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      TargetMol | Citations Cited
    • Progesterone
      T047857-83-0
      Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.
      • $38
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    • Bazedoxifene hydrochloride
      T6404198480-56-7
      Bazedoxifene hydrochloride (TSE 424 hydrochloride) is an orally active, selective, and potent estrogen receptor modulator (SERM) that crosses the blood-brain barrier and is an inhibitor of IL-6 GP130 protein interactions with high affinity for ERα and ERβ. It has a high affinity for ERα and ERβ and can be used to study postmenopausal osteoporosis and vasodilator-related diseases.
      • $55
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    • Isopsoralenoside
      TN1148905954-18-9
      Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
      • $106
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    • Bavachin
      T384619879-32-4
      Bavachin (Corylifolin) is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
      • $30
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    • Ethynyl estradiol
      T142457-63-6
      Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
      • $32
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    • Dienestrol
      T003584-17-3
      Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.
      • $30
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    • PHTPP
      T4388805239-56-9
      PHTPP is a selective ERβ antagonist.
      • $30
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    • Endoxifen
      T4281110025-28-0
      (E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.
      • $41
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    • Melatonin
      T165973-31-4
      Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
      • $31
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    • Norethindrone
      T151468-22-4
      Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
      • $38
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    • kaempferide
      T3806491-54-3
      kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.
      • $80
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    • Endoxifen Z-isomer hydrochloride
      T68271032008-74-4
      Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
      • $46
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    • Estradiol benzoate
      T038450-50-0
      Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
      • $45
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