Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Atabecestat

🥰Excellent
Catalog No. T14338Cas No. 1200493-78-2
Alias RSC-385896, JNJ-54861911

Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].

Atabecestat

Atabecestat

🥰Excellent
Purity: 99.77%
Catalog No. T14338Alias RSC-385896, JNJ-54861911Cas No. 1200493-78-2
Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$132In StockIn Stock
5 mg$328In StockIn Stock
10 mg$529In StockIn Stock
25 mg$1,060In StockIn Stock
50 mg$1,420In StockIn Stock
100 mg$1,920-In Stock
1 mL x 10 mM (in DMSO)$363In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.77%
Contact us for more batch information

Resource Download

COA LCMS

Product Introduction

Bioactivity
Description
Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
In vivo
In 5-week-old APPPS1 mice, Atabecestat (100 and 300 mg/kg; oral gavage; once daily for 3 days) reduced the levels of human Aβ1-40 and Aβ1-42 in the brain of APPPS1 mice at a dose of 300 mg/kg, and resulted in less reduction of human Aβ levels at 24 hours with a dose of 100 mg/kg[2].
SynonymsRSC-385896, JNJ-54861911
Chemical Properties
Molecular Weight367.4
FormulaC18H14FN5OS
Cas No.1200493-78-2
SmilesC[C@]1(C=CSC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Relative Density.1.39 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (544.37 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7218 mL13.6091 mL27.2183 mL136.0915 mL
5 mM0.5444 mL2.7218 mL5.4437 mL27.2183 mL
10 mM0.2722 mL1.3609 mL2.7218 mL13.6091 mL
20 mM0.1361 mL0.6805 mL1.3609 mL6.8046 mL
50 mM0.0544 mL0.2722 mL0.5444 mL2.7218 mL
100 mM0.0272 mL0.1361 mL0.2722 mL1.3609 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

JNJ54861911JNJ 54861911BACE1Atabecestat
Related Tags: buy Atabecestat | purchase Atabecestat | Atabecestat cost | order Atabecestat | Atabecestat chemical structure | Atabecestat in vivo | Atabecestat formula | Atabecestat molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.