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BL-918

Name: BL-918
Brand: TargetMol
SKU: T8322
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8322Cas No. 2101517-69-3

BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.

BL-918

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Purity: 99.4%

Catalog No. T8322Cas No. 2101517-69-3

BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.

Pack Size	Price	Availability
1 mg	$45	In Stock
2 mg	$64	In Stock
5 mg	$106	In Stock
10 mg	$158	In Stock
25 mg	$298	In Stock
50 mg	$479	In Stock
100 mg	$787	In Stock
500 mg	$1,580	In Stock
1 mL x 10 mM (in DMSO)	$129	In Stock

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Purity:99.4%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.
Targets&IC50	ULK1:24.14 nM(EC50), ULK1:0.719 μM (Kd)

Chemical Properties

Molecular Weight	533.44
Formula	C₂₃H₁₅F₈N₃OS
Cas No.	2101517-69-3
Smiles	Fc1ccc(NC(=O)[C@H](NC(=S)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2ccccc2)c(F)c1
Relative Density.	1.508 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (51.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8746 mL	9.3731 mL	18.7463 mL	93.7313 mL
5 mM	0.3749 mL	1.8746 mL	3.7493 mL	18.7463 mL
10 mM	0.1875 mL	0.9373 mL	1.8746 mL	9.3731 mL
20 mM	0.0937 mL	0.4687 mL	0.9373 mL	4.6866 mL
50 mM	0.0375 mL	0.1875 mL	0.3749 mL	1.8746 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc