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Anti-ICAM-1/CD54 Antibody (3L636)
🥰Excellent
Catalog No. TMAY-03693
Anti-ICAM-1/CD54 Antibody (3L636) is a Mouse antibody targeting ICAM-1/CD54. Anti-ICAM-1/CD54 Antibody (3L636) can be used in IHC-P.
Anti-ICAM-1/CD54 Antibody (3L636)
Anti-ICAM-1/CD54 Antibody (3L636)
🥰Excellent
Catalog No. TMAY-03693
Anti-ICAM-1/CD54 Antibody (3L636) is a Mouse antibody targeting ICAM-1/CD54. Anti-ICAM-1/CD54 Antibody (3L636) can be used in IHC-P.
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-ICAM-1/CD54 Antibody (3L636) is a Mouse antibody targeting ICAM-1/CD54. Anti-ICAM-1/CD54 Antibody (3L636) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 3L636 |
| Reactivity | Rat |
| Verified Activity | 1. Immunochemical staining of rat ICAM1 in rat liver with mouse monoclonal antibody at 1:30 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of rat ICAM1 in rat lung with mouse monoclonal antibody at 1:30 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of rat ICAM1 in rat kidney with mouse monoclonal antibody at 1:30 dilution, formalin-fixed paraffin embedded sections. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:20-1:50 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat ICAM-1 (rR ICAM-1; TMPY-02017; Q00238-1; Met1-Thr493). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rat ICAM-1 Protein (TMPY-02017) |
| Antigen Species | Rat |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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