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Alpha-Estradiol

Name: Alpha-Estradiol
Brand: TargetMol
SKU: T3378
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3378Cas No. 57-91-0

Alias Epiestrol, Epiestradiol, Alfatradiol, 17α-Estradiol

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

Alpha-Estradiol

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Purity: 99.86%

Catalog No. T3378Alias Epiestrol, Epiestradiol, Alfatradiol, 17α-EstradiolCas No. 57-91-0

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$50	In Stock	In Stock
500 mg	$83	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.86%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.
Kinase Assay	Na+-Ca2+ exchange activity is determined by assaying Na+-dependent 45Ca2+ uptake as reported previously. Briefly, the cells are preincubated in Hanks' balanced saline solution (HBSS) for 20 min, and the medium is switched to HBSS containing 45Ca2+?and incubated for 5 min. To increase intracellular Na+?concentration, 1 mM ouabain plus 20 μM monensin (for astrocytes and microglia) and 10 μM monensin (for neurons) are used. Monensin is added simultaneously with the isotope. Ouabain is added 5 min before monensin in astrocytes and microglia. SEA0400 and KB-R7943 are added 5 min before monensin and present during 45Ca2+?uptake reaction.
Synonyms	Epiestrol, Epiestradiol, Alfatradiol, 17α-Estradiol

Chemical Properties

Molecular Weight	272.38
Formula	C₁₈H₂₄O₂
Cas No.	57-91-0
Smiles	C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC[C@H]2O)[H]
Relative Density.	1.0708 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (229.46 mM), Sonication is recommended.

Ethanol: 11.11 mg/mL (40.79 mM), Sonication is recommended.

In Vivo Formulation

10% Corn oil+90% Salin: 4 mg/mL (14.69 mM), Sonication is recommended.

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 4 mg/mL (14.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6713 mL	18.3567 mL	36.7134 mL	183.5671 mL
5 mM	0.7343 mL	3.6713 mL	7.3427 mL	36.7134 mL
10 mM	0.3671 mL	1.8357 mL	3.6713 mL	18.3567 mL
20 mM	0.1836 mL	0.9178 mL	1.8357 mL	9.1784 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0734 mL	0.3671 mL	0.7343 mL	3.6713 mL
100 mM	0.0367 mL	0.1836 mL	0.3671 mL	1.8357 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc