TIE2 Protein, Mouse, Recombinant (His)

Name: TIE2 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-07215
Rating: 4.5 (1 reviews)

(Synonyms: Tie-2, Tie2, Tek, STK1, Hyk, Cd202b) Copy Product Info

Synonyms: Tie-2, Tie2, Tek, STK1, Hyk, Cd202b

Catalog No. TMPY-07215 Copy Product Info

TIE2 Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q02858.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$50	7-10 days	7-10 days
10 µg	$78	7-10 days	7-10 days
20 µg	$125	7-10 days	7-10 days
50 µg	$243	7-10 days	7-10 days
100 µg	$396	7-10 days	7-10 days
200 µg	$682	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA.Immobilized mouse TEK-His at 10 μg/ml (100 μl/well) can bind human Ang2-Fc with a linear range of 6.25-200 ng/ml.
Description	TIE2 Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q02858.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q02858
Construction	A DNA sequence encoding the mouse TEK (Q02858) (Met1-Lys744) was expressed with a C-terminal polyhistidine tag.
Protein Purity	≥ 90% as determined by SDS-PAGE. ≥ 90% as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Please refer to the lot-specific COA.
Synonyms	Tie-2, Tie2, Tek, STK1, Hyk, Cd202b
Research Background	TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

Chemical Properties

Molecular Weight

82 kDa (predicted); 91 kDa (reducing contition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.