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PROTAC BRAF-V600E degrader-1

Name: PROTAC BRAF-V600E degrader-1
Brand: TargetMol
SKU: T8745
Price: 115 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8745Cas No. 2417296-84-3

Alias Compound 23

PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.

PROTAC BRAF-V600E degrader-1

🥰Excellent

Purity: 99.43%

Catalog No. T8745Alias Compound 23Cas No. 2417296-84-3

PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$115	In Stock	In Stock
5 mg	$319	In Stock	In Stock
10 mg	$418	In Stock	In Stock
25 mg	$683	In Stock	In Stock
50 mg	$922	-	In Stock
100 mg	$1,230	-	In Stock
200 mg	$1,670	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.43%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
Targets&IC50	B-Raf:2.4 nM (Kd), B-Raf (V600E):2 nM (Kd)
Synonyms	Compound 23

Chemical Properties

Molecular Weight	1001.07
Formula	C₄₈H₅₄F₂N₁₀O₁₀S
Cas No.	2417296-84-3
Smiles	FC1=C(N2C=3C(C(=C2)C=4C=NC=NC4)=NC(N(C)C5CCN(C(CCOCCOCCOCCNC6=C7C(C(=O)N(C7=O)C8C(=O)NC(=O)CC8)=CC=C6)=O)CC5)=CC3)C(F)=CC=C1NS(CCC)(=O)=O
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9989 mL	4.9947 mL	9.9893 mL	49.9466 mL
5 mM	0.1998 mL	0.9989 mL	1.9979 mL	9.9893 mL
10 mM	0.0999 mL	0.4995 mL	0.9989 mL	4.9947 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc