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3,5-Diiodo-L-thyronine
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Catalog No. T4461Cas No. 1041-01-6
Alias Diiodothyronine
3,5-Diiodo-L-thyronine (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.
3,5-Diiodo-L-thyronine
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Purity: 99.64%
Catalog No. T4461Alias DiiodothyronineCas No. 1041-01-6
3,5-Diiodo-L-thyronine (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.64%
Appearance:Solid
Color:White
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Product Introduction
3,5-Diiodo-L-thyronine AI Summary
3,5-Diiodo-L-thyronine exhibits multifaceted bioactivity related to thyroid hormone functions, RGS4 inhibition, and PCNA interaction inhibition. It shows high relative binding affinity for T3 thyroid hormone nuclear receptors in both rat liver (IC50 ratio of 0.08) and rat heart (IC50 ratio of 0.4), indicating strong potential as a thyroid hormone agonist or modulator. It demonstrates thyromimetic activity by inducing GPDH enzyme in rat liver (ED50 ratio of 1.1) and rat heart (ED50 ratio of 0.45), and has a pKa of 9.99. Additionally, 3,5-Diiodo-L-thyronine inhibits the Regulator of G Protein Signaling (RGS) 4 with a potency of 8436.8 nM and has no activity towards human recombinant UGT1A6, UGT1A9, and UGT1A1 enzymes. It also inhibits the interaction of human recombinant PCNA with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK with an IC50 value of 6300.0 nM. Lastly, in an antigoiter assay in rats, it shows thyroxine-like activity at 10.0% relative to control, with the log of the activity being 1.0..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3,5-Diiodo-L-thyronine (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance. |
| Synonyms | Diiodothyronine |
| Molecular Weight | 525.08 |
| Formula | C15H13I2NO4 |
| Cas No. | 1041-01-6 |
| Smiles | N[C@@H](Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1)C(O)=O |
| Relative Density. | 2.095 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble)  |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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