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Aldometanib

Catalog No. T60122 CAS 2904601-67-6

Synonyms: Compound IA-47 (Br- base 2246625-81-8)

Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AMPK. Aldometanib can be used for the research of metabolic homeostasis [1].

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Aldometanib, CAS 2904601-67-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 83.00
10 mg	In stock	$ 132.00
25 mg	In stock	$ 288.00
1 mL * 10 mM (in DMSO)	In stock	$ 136.00

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Purity: 100%

Biological Description

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Description	Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AMPK. Aldometanib can be used for the research of metabolic homeostasis [1].
In vitro	Aldometanib (0-1000 nM; 2 h) activates AMPK through preventing aldolase from binding to FBP to engender a pseudo-starvation signal [1]. Western Blot Analysis [1] Cell Line: Mouse primary hepatocytes, MEFs cells Concentration: 0-1000 nM Incubation Time: 2 h Result: Activated AMPK in mouse embryonic fibroblasts (MEFs) and mouse primary hepatocytes cells. Immunofluorescence [1] Cell Line: MEFs cells Concentration: 5 nM Incubation Time: 2 h Result: Inhibited TRPVs and induces AXIN lysosomal translocation.
In vivo	Aldometanib, administered orally at dosages ranging from 0-10 mpk, effectively reduces blood glucose levels in lean mice and, when given at 2-10 mpk twice daily for a week, mitigates blood glucose and ameliorates fatty liver in obese hyperglycemic mice. Additionally, it addresses fatty liver and nonalcoholic steatohepatitis issues, and a regimen of 2 mpk twice daily over a month alleviates liver fibrosis in NASH mice. Moreover, Aldometanib extends the lifespan of C. elegans through the lysosomal pathway when administered orally at 0-50 μM for up to 50 days. In lean mice, dosages of 0-10 mpk lower fasting blood glucose, enhance glucose tolerance, and promote muscular TBC1D1 phosphorylation for glucose uptake. In obese hyperglycemic mice, a week-long administration of 2-10 mpk effectively lowers blood glucose, decreases hepatic TAG, and enhances insulin sensitivity through muscular AMPK dependencies, also diminishing fat mass. For NASH mice, a month-long administration of 2 mpk results in the reduction of NASH diagnostic histological scores, decreased hepatic cell apoptosis, reduced inflammatory liver responses, and improved glucose tolerance. In C. elegans, dosages of 0-50 μM improve oxidative stress resistance and bolster mitochondrial functions, while for C57BL/6 mice, administering 100 μg/mL orally rejuvenates muscle function and extends lifespan by increasing NAD+ levels and mitochondrial oxidative respiration.

Synonyms	Compound IA-47 (Br- base 2246625-81-8)
Molecular Weight	593.46
Formula	C27H43Cl2IN2
CAS No.	2904601-67-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (101.1 mM)

References and Literature

1. Zhang CS, et al. The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat Metab. 2022 Oct;4(10):1369-1401.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Anti-Ovarian Cancer Compound Library Mitochondria-Targeted Compound Library Antioxidant Compound Library Epigenetics Compound Library Anti-Obesity Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max AMPK-Targeted Compound Library

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Keywords

Aldometanib 2904601-67-6 Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling AMPK CompoundIA47 Compound IA-47 (Br- base 2246625-81-8) Br- base 2246625-81-8 Compound IA-47 inhibitor inhibit

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