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L-Cycloserine
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Catalog No. T0710Cas No. 339-72-0
Alias Levcycloserinum, Levcycloserine, Levcicloserina, (S)-Cycloserine, (S)-4-Amino-3-isoxazolidone, (-)-Cycloserine
L-Cycloserine ((-)-Cycloserine) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo.
L-Cycloserine
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Purity: 99.99%
Catalog No. T0710Alias Levcycloserinum, Levcycloserine, Levcicloserina, (S)-Cycloserine, (S)-4-Amino-3-isoxazolidone, (-)-CycloserineCas No. 339-72-0
L-Cycloserine ((-)-Cycloserine) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $30 | - | In Stock | |
| 10 mg | $46 | - | In Stock | |
| 50 mg | $67 | - | In Stock | |
| 100 mg | $97 | - | In Stock | |
| 200 mg | $143 | - | In Stock | |
| 500 mg | $238 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.99%
Color:White to Yellow
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Product Introduction
L-Cycloserine AI Summary
L-Cycloserine exhibits a broad range of bioactivities across various biological targets. It acts as an inhibitor of Concanavalin A-stimulated cell proliferation in mouse splenocytes with an IC50 of 3500.0 nM after 48 hours as measured by the MTT assay. Additionally, it shows inhibition of Endonuclease IV (potency of 891.3 nM), Bloom's syndrome helicase (BLM) with inhibitory concentrations of 2.8 nM, and Histone Lysine Methyltransferase G9a with potencies of 21192.3 nM and 22.4 nM. Moreover, L-Cycloserine demonstrates activity against several other targets, including HP1-beta Chromodomain Interactions, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and viral entry mechanisms for both Lassa and Marburg viruses. It also shows moderate activity in antimicrobial applications, inhibiting Mycobacterium tuberculosis H37Rv and multiple bacterial strains such as Staphylococcus aureus and Enterococcus faecalis, where minimum inhibitory concentration (MIC) values range from 157,000.0 to greater than 5,015,000.0 nM. Furthermore, it displays antiviral activity against SARS-CoV-2 with a noted inhibition index of 1.42 in cell viability assays of infected Vero E6 cells although its IC50 values are higher than 20,000.0 nM in other antiviral assays. Lastly, it inhibits human PAT1-mediated L-[3H]proline uptake with a Ki of 7400000.0 nM and shows marginal inhibition of enzymes like electric eel AChE (1.18% at 2 mg/ml) and horse BChE (-5.13% at the same concentration)..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Cycloserine ((-)-Cycloserine) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo. |
| Synonyms | Levcycloserinum, Levcycloserine, Levcicloserina, (S)-Cycloserine, (S)-4-Amino-3-isoxazolidone, (-)-Cycloserine |
| Molecular Weight | 102.09 |
| Formula | C3H6N2O2 |
| Cas No. | 339-72-0 |
| Smiles | [C@H]1(N)CONC1=O |
| Relative Density. | 1.278 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 7.1 mg/mL (69.55 mM), Sonication is recommended.  H2O: Insoluble | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (9.8 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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