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Anti-CDK7 Antibody (3Y405)
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Catalog No. TMAC-00801
Alias TFIIH basal transcription factor complex kinase subunit, STK1, Serine/threonine-protein kinase 1, MO15, Cyclin-dependent kinase 7, Cell division protein kinase 7, CDKN7, CDK-activating kinase 1, CDK7, CAK1, CAK, 39 kDa protein kinase (p39 Mo15)
Anti-CDK7 Antibody (3Y405) is a Rabbit antibody targeting CDK7. Anti-CDK7 Antibody (3Y405) can be used in WB,ICC/IF,IHC,FCM.
Anti-CDK7 Antibody (3Y405)
Anti-CDK7 Antibody (3Y405)
😃Good
Catalog No. TMAC-00801Alias TFIIH basal transcription factor complex kinase subunit, STK1, Serine/threonine-protein kinase 1, MO15, Cyclin-dependent kinase 7, Cell division protein kinase 7, CDKN7, CDK-activating kinase 1, CDK7, CAK1, CAK, 39 kDa protein kinase (p39 Mo15)
Anti-CDK7 Antibody (3Y405) is a Rabbit antibody targeting CDK7. Anti-CDK7 Antibody (3Y405) can be used in WB,ICC/IF,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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| Description | Anti-CDK7 Antibody (3Y405) is a Rabbit antibody targeting CDK7. Anti-CDK7 Antibody (3Y405) can be used in WB,ICC/IF,IHC,FCM. |
| Synonyms | TFIIH basal transcription factor complex kinase subunit, STK1, Serine/threonine-protein kinase 1, MO15, Cyclin-dependent kinase 7, Cell division protein kinase 7, CDKN7, CDK-activating kinase 1, CDK7, CAK1, CAK, 39 kDa protein kinase (p39 Mo15) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Cdk7 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Cdk7 antibody. Counter stained with hematoxylin. 3. ICC staining Cdk7 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining Cdk7 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Cdk7 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining Cdk7 in 293 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of A431 cells with Cdk7 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Progression through the cell cycle requires activation of a series of enzymes designated cyclin dependent kinases (Cdks). The monomeric catalytic subunit Cdk2, a critical enzyme for initiation of cell cycle progression, is completely inactive. Partial activation is achieved by the binding of regulatory cyclins such as cyclin D1, while full activation requires additional phosphorylation at Thr 160. The enzyme responsible for the phosphorylation of Cdk2 on Thr 160 and also of Cdc2 p34 on Thr 161, designated Cdk-activating kinase (CAK), has been partially purified and shown to be comprised of a catalytic subunit and a regulatory subunit. The catalytic subunit, designated Cdk7, has been identified as the mammalian homolog of MO15, a protein kinase demonstrated in starfish and Xenopus. The regulatory subunit is a novel cyclin (cyclin H) and is required for activation of Cdk7. Like other Cdks, Cdk7 contains a conserved threonine residue required for full activity; mutation of this residue severely reduces CAK activity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 39 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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