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Ibutamoren (Synonyms: MK-677, MK677, MK 677, L-163191, L163191, L 163191)

Name: Ibutamoren
Brand: TargetMol
SKU: T20095
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T20095 Copy Product Info

Purity: 97.59%

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Ibutamoren (MK-677) is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It also alters the metabolism of body fat and so may have an application in the treatment of obesity.

Ibutamoren

Copy Product Info

😃Good

Catalog No. T20095

Synonyms MK-677, MK677, MK 677, L-163191, L163191, L 163191

Cas No. 159634-47-6

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.59%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Ibutamoren AI Summary

Ibutamoren exhibits potent bioactivity related to growth hormone secretion and strong binding affinity to growth hormone secretagogue receptors. In vitro assays demonstrate an EC50 value of 1.3 nM for stimulating growth hormone release from rat pituitary cells, and the compound shows high binding affinity to the human Growth Hormone Secretagogue Receptor type 1, with IC50 values ranging from 0.4 to 0.63 nM. Additionally, the compound displays competitive antagonistic activity against ghrelin and significant agonist activity, achieving up to 90% of the response of the reference compound, GHRP-6. In vivo studies confirm its bioactivity, with a low ED50 value of 0.084 µmol/kg for stimulating growth hormone release in pigs. Furthermore, Ibutamoren exhibits multi-faceted bioactivity, including a moderate binding affinity in different assays and moderate plasma protein binding across species. It has also shown some level of antiviral activity against SARS-CoV-2 and inhibitory activity against the human HDAC6 enzyme. Overall, Ibutamoren demonstrates significant potential in modulating growth hormone pathways and other biological activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ibutamoren (MK-677) is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It also alters the metabolism of body fat and so may have an application in the treatment of obesity.
Synonyms	MK-677, MK677, MK 677, L-163191, L163191, L 163191

Chemical Properties

Molecular Weight	528.66
Formula	C₂₇H₃₆N₄O₅S
Cas No.	159634-47-6
Smiles	S(C)(=O)(=O)N1CC2(C=3C1=CC=CC3)CCN(C([C@@H](COCC4=CC=CC=C4)NC(C(C)(C)N)=O)=O)CC2
Relative Density.	1.32g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (52.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8916 mL	9.4579 mL	18.9157 mL	94.5787 mL
5 mM	0.3783 mL	1.8916 mL	3.7831 mL	18.9157 mL
10 mM	0.1892 mL	0.9458 mL	1.8916 mL	9.4579 mL
20 mM	0.0946 mL	0.4729 mL	0.9458 mL	4.7289 mL
50 mM	0.0378 mL	0.1892 mL	0.3783 mL	1.8916 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc