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GPR34 receptor antagonist 2

Name: GPR34 receptor antagonist 2
Brand: TargetMol
SKU: T8848
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8848Cas No. 907952-06-1

Alias Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-, gpr34-receptor-antagonist-2

GPR34 receptor antagonist 2 (Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-) is an anti-inflammatory agent.

GPR34 receptor antagonist 2

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Purity: 97.26%

Catalog No. T8848Alias Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-, gpr34-receptor-antagonist-2Cas No. 907952-06-1

GPR34 receptor antagonist 2 (Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-) is an anti-inflammatory agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$288	In Stock	In Stock
10 mg	$473	In Stock	In Stock
25 mg	$777	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock
100 mg	$1,460	In Stock	In Stock
500 mg	$2,930	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$319	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.26%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

GPR34 receptor antagonist 2 AI Summary

GPR34 receptor antagonist 2 exhibits antagonist activity against human lung GPR34, effectively inhibiting the lysophosphatidyl serine-induced increase in intracellular calcium levels in CHO cells expressing Galpha116, with an IC50 value of less than or equal to 1000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	GPR34 receptor antagonist 2 (Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-) is an anti-inflammatory agent.
Synonyms	Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-, gpr34-receptor-antagonist-2

Chemical Properties

Molecular Weight	512
Formula	C₃₁H₂₆ClNO₄
Cas No.	907952-06-1
Smiles	OC(=O)C(Cc1ccc(OCc2ccccc2)cc1)NC(=O)\C=C\c1ccc(cc1)-c1ccc(Cl)cc1
Relative Density.	1.268 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 80 mg/mL (156.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9531 mL	9.7656 mL	19.5313 mL	97.6563 mL
5 mM	0.3906 mL	1.9531 mL	3.9063 mL	19.5313 mL
10 mM	0.1953 mL	0.9766 mL	1.9531 mL	9.7656 mL
20 mM	0.0977 mL	0.4883 mL	0.9766 mL	4.8828 mL
50 mM	0.0391 mL	0.1953 mL	0.3906 mL	1.9531 mL
100 mM	0.0195 mL	0.0977 mL	0.1953 mL	0.9766 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc