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Navitoclax-piperazine

Name: Navitoclax-piperazine
Brand: TargetMol
SKU: T12186
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12186Cas No. 2143096-93-7

Alias ABT-263-piperazine

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor.

Navitoclax-piperazine

🥰Excellent

Purity: 99.82%

Catalog No. T12186Alias ABT-263-piperazineCas No. 2143096-93-7

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor.

Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$166	In Stock
10 mg	$287	In Stock
25 mg	$453	In Stock
50 mg	$592	In Stock
100 mg	$833	In Stock
200 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor.
Synonyms	ABT-263-piperazine

Chemical Properties

Molecular Weight	973.63
Formula	C₄₇H₅₆ClF₃N₆O₅S₃
Cas No.	2143096-93-7
Smiles	CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCNCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (256.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0271 mL	5.1354 mL	10.2708 mL	51.3542 mL
5 mM	0.2054 mL	1.0271 mL	2.0542 mL	10.2708 mL
10 mM	0.1027 mL	0.5135 mL	1.0271 mL	5.1354 mL
20 mM	0.0514 mL	0.2568 mL	0.5135 mL	2.5677 mL
50 mM	0.0205 mL	0.1027 mL	0.2054 mL	1.0271 mL
100 mM	0.0103 mL	0.0514 mL	0.1027 mL	0.5135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc