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PTP inhibitor 1

Name: PTP inhibitor 1
Brand: TargetMol
SKU: T7541
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7541Cas No. 2632-13-5

Alias PTP Inhibitor II

PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM.

PTP inhibitor 1

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Purity: 99.51%

Catalog No. T7541Alias PTP Inhibitor IICas No. 2632-13-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

PTP inhibitor 1 AI Summary

PTP inhibitor 1 is a potential inhibitor of Protein-tyrosine phosphatase 1B (PTP1B) with a dissociation constant (Ki) of 128000.0 nM and a first-order rate constant (kinact) of 2.4 min^-1 for converting the complex into a covalent adduct, resulting in a Ki/kinact ratio of 18000.0 M^-1 min^-1. The compound also exhibits significant inhibitory activity against glycogen synthase kinase-3 beta (GSK-3β) with an IC50 value of 1000.0 nM as determined by radiometric or scintillation counting assays using GS-1 as a substrate in the presence of [gamma-32P]ATP. Additionally, PTP inhibitor 1 shows inhibitory activity against protein kinase A (PKA) with an IC50 value greater than 100000.0 nM. These findings suggest that PTP inhibitor 1 may have therapeutic potential as a multi-targeted kinase inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM.
Targets&IC50	SHP1 (ΔSH2, cell-free assay):128 μM(Ki)
Synonyms	PTP Inhibitor II

Chemical Properties

Molecular Weight	229.07
Formula	C₉H₉BrO₂
Cas No.	2632-13-5
Smiles	COC1=CC=C(C=C1)C(=O)CBr
Relative Density.	1.448 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (240.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3655 mL	21.8274 mL	43.6548 mL	218.2739 mL
5 mM	0.8731 mL	4.3655 mL	8.7310 mL	43.6548 mL
10 mM	0.4365 mL	2.1827 mL	4.3655 mL	21.8274 mL
20 mM	0.2183 mL	1.0914 mL	2.1827 mL	10.9137 mL
50 mM	0.0873 mL	0.4365 mL	0.8731 mL	4.3655 mL
100 mM	0.0437 mL	0.2183 mL	0.4365 mL	2.1827 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc