Anti-Phospho-IkB alpha/NFKBIA (Ser32, 36) Antibody (7S693)

Name: Anti-Phospho-IkB alpha/NFKBIA (Ser32, 36) Antibody (7S693)
Brand: TargetMol
SKU: TMAB-01425
Rating: 4.5 (1 reviews)

(Synonyms: p-IkB alpha/NFKBIA (Ser32, 36), p-IkB alpha/NFKBIA (S32, 36), nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, α, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, NFKBI, MAD-3, IKBA, IkB α, IkB alpha/NFKBIA (p-Ser32, 36), IkB alpha/NFKBIA (p-S32, 36)) Copy Product Info

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Synonyms: p-IkB alpha/NFKBIA (Ser32, 36), p-IkB alpha/NFKBIA (S32, 36), nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, α, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, NFKBI, MAD-3, IKBA, IkB α, IkB alpha/NFKBIA (p-Ser32, 36), IkB alpha/NFKBIA (p-S32, 36)

Catalog No. TMAB-01425 Copy Product Info

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Anti-Phospho-IkB alpha/NFKBIA (Ser32, 36) Antibody (7S693) is a Rabbit antibody targeting Phospho-IkB alpha/NFKBIA (Ser32, 36). Anti-Phospho-IkB alpha/NFKBIA (Ser32, 36) Antibody (7S693) can be used in IF, IHC-Fr, IHC-P, WB.

Anti-Phospho-IkB alpha/NFKBIA
(Ser32, 36) Antibody
(7S693)

Pack Size	Price	USA Stock	Global Stock
25 μL	$154	7-10 days	7-10 days
50 μL	$271	7-10 days	7-10 days
100 μL	$489	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-Phospho-IkB alpha/NFKBIA (Ser32, 36) Antibody (7S693) is a Rabbit antibody targeting Phospho-IkB alpha/NFKBIA (Ser32, 36). Anti-Phospho-IkB alpha/NFKBIA (Ser32, 36) Antibody (7S693) can be used in IF, IHC-Fr, IHC-P, WB.
Synonyms	p-IkB alpha/NFKBIA (Ser32, 36), p-IkB alpha/NFKBIA (S32, 36), nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, α, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, NFKBI, MAD-3, IKBA, IkB α, IkB alpha/NFKBIA (p-Ser32, 36), IkB alpha/NFKBIA (p-S32, 36)
Ig Type	IgG
Clone	7S693
Reactivity	Human,Mouse,Rat

Application	IF IHC-Fr IHC-P WB
Recommended Dose	IF=1:50-200; IHC-Fr=1:50-200; IHC-P=1:50-200; WB=1:500-2000
Antibody Type	Monoclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Tissue Specificity	Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract.
Construction	Recombinant Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human phospho-IKB Alpha (Ser32 / Ser36)
Antigen Species	Human
Gene Name	NFKBIA
Gene ID	4792
Protein Name	NF-kappa-B inhibitor alpha
Uniprot ID	P25963
Biology Area	NFkB pathway,NFkB pathway,TLR Signaling,NFkB Pathway
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.