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AR-M 1896 Acetate

Name: AR-M 1896 Acetate
Brand: TargetMol
SKU: T21646L
Price: 339 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21646L

Alias AR-M 1896 Acetate (367518-31-8 Free base)

AR-M 1896 Acetate is the selective agonist of GalR2.

AR-M 1896 Acetate

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Purity: 99.76%

Catalog No. T21646LAlias AR-M 1896 Acetate (367518-31-8 Free base)

AR-M 1896 Acetate is the selective agonist of GalR2.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$339	In Stock	In Stock
5 mg	$672	In Stock	In Stock
10 mg	$918	In Stock	In Stock
25 mg	$1,350	In Stock	In Stock
50 mg	$1,780	In Stock	In Stock
100 mg	$2,380	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$1,390	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.76%

Appearance:Solid

Color:Yellow

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COA MS LCMS

Product Introduction

Bioactivity

Description	AR-M 1896 Acetate is the selective agonist of GalR2.
Targets&IC50	GalR2:1.76 nM, GalR1 (human):879 Nm
In vitro	Removal of the glycine residue in position 1 resulted in AR-M1896 with almost unchanged GalR2 affinity and functional activity, and 500-fold selectivity for GalR2-Rs over GalR1-Rs[1].?
In vivo	In normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. The same effect is seen with equimolar doses of AR-M1896 or AR-M961 (an agonist both at GalR1 and GalR2 receptors). In allodynic Bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high AR-M961dose, whereas no effect was observed in the control or AR-M1896 group. No effect of either compounds was observed in nonallodynic Bennett model rats[1].
Synonyms	AR-M 1896 Acetate (367518-31-8 Free base)

Chemical Properties

Molecular Weight	1196.35
Formula	C₅₆H₈₅N₁₃O₁₆
Smiles	CC(O)=O.CC(C)C[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CC2=CNC3=C2C=CC=C3)N)=O)=O)=O)=O)=O)=O)=O)=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (45.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8359 mL	4.1794 mL	8.3588 mL	41.7938 mL
5 mM	0.1672 mL	0.8359 mL	1.6718 mL	8.3588 mL
10 mM	0.0836 mL	0.4179 mL	0.8359 mL	4.1794 mL
20 mM	0.0418 mL	0.2090 mL	0.4179 mL	2.0897 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc