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MK-4827 Racemate

Name: MK-4827 Racemate
Brand: TargetMol
SKU: T22988
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22988Cas No. 1038915-75-1

Alias Niraparib Racemate, 2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide

MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1.

MK-4827 Racemate

🥰Excellent

Purity: 99.86%

Catalog No. T22988Alias Niraparib Racemate, 2-(4-piperidin-3-ylphenyl)indazole-7-carboxamideCas No. 1038915-75-1

MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
2 mg	$63	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$518	In Stock	In Stock
100 mg	$698	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$121	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.86%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1.
Targets&IC50	PARP1:3.8 nM, PARP2:2.1 nM
Synonyms	Niraparib Racemate, 2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide

Chemical Properties

Molecular Weight	320.39
Formula	C₁₉H₂₀N₄O
Cas No.	1038915-75-1
Smiles	NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C1CCCNC1
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (187.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1212 mL	15.6060 mL	31.2120 mL	156.0598 mL
5 mM	0.6242 mL	3.1212 mL	6.2424 mL	31.2120 mL
10 mM	0.3121 mL	1.5606 mL	3.1212 mL	15.6060 mL
20 mM	0.1561 mL	0.7803 mL	1.5606 mL	7.8030 mL
50 mM	0.0624 mL	0.3121 mL	0.6242 mL	3.1212 mL
100 mM	0.0312 mL	0.1561 mL	0.3121 mL	1.5606 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc