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5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
Pack Size | Price | Availability | Quantity |
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500 mg | $45 | In Stock |
Description | 5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN). |
Targets&IC50 | contractile leukotriene:2.3 mM |
In vitro | METHODS: HEK293 cells carrying the pendrin P123S mutant were treated with 5-Aminosalicylic Acid for 72 hours, and cytotoxicity was detected by the MTT method. RESULTS: The IC50 of 5-Aminosalicylic Acid on HEK293 cells carrying the pendrin P123S mutant was >15 mM. [1] |
In vivo | METHODS: To study the anti-tumor activity of 5-Aminosalicylic Acid, 5-Aminosalicylic Acid (50 mM) was administered to SCID mice inoculated with HT-29 colon cancer cells for 21 consecutive days. RESULTS: The tumor weight and volume of SCID mice treated with 5-Aminosalicylic acid were reduced by 80-86%. [2] |
Synonyms | Mesalazine, Mesalamine, 5-ASA |
Molecular Weight | 153.14 |
Formula | C7H7NO3 |
Cas No. | 89-57-6 |
Smiles | NC1=CC(C(O)=O)=C(O)C=C1 |
Relative Density. | 1.3585 g/cm3 (Estimated) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 29 mg/mL (189.37 mM), Sonication is recommended. DMSO: 60 mg/mL (391.8 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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