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5-Aminosalicylic Acid

Name: 5-Aminosalicylic Acid
Brand: TargetMol
SKU: T0646
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0646Cas No. 89-57-6

Alias Mesalazine, Mesalamine, 5-ASA

5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

5-Aminosalicylic Acid

🥰Excellent

Purity: 99.49%

Catalog No. T0646Alias Mesalazine, Mesalamine, 5-ASACas No. 89-57-6

Pack Size	Price	Availability	Quantity
500 mg	$45	In Stock

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Purity:99.49%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
Targets&IC50	contractile leukotriene:2.3 mM
In vitro	METHODS: HEK293 cells carrying the pendrin P123S mutant were treated with 5-Aminosalicylic Acid for 72 hours, and cytotoxicity was detected by the MTT method. RESULTS: The IC50 of 5-Aminosalicylic Acid on HEK293 cells carrying the pendrin P123S mutant was >15 mM. [1]
In vivo	METHODS: To study the anti-tumor activity of 5-Aminosalicylic Acid, 5-Aminosalicylic Acid (50 mM) was administered to SCID mice inoculated with HT-29 colon cancer cells for 21 consecutive days. RESULTS: The tumor weight and volume of SCID mice treated with 5-Aminosalicylic acid were reduced by 80-86%. [2]
Synonyms	Mesalazine, Mesalamine, 5-ASA

Chemical Properties

Molecular Weight	153.14
Formula	C₇H₇NO₃
Cas No.	89-57-6
Smiles	NC1=CC(C(O)=O)=C(O)C=C1
Relative Density.	1.3585 g/cm3 (Estimated)
Color	Red
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 29 mg/mL (189.37 mM), Sonication is recommended.

DMSO: 80 mg/mL (522.4 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5300 mL	32.6499 mL	65.2997 mL	326.4986 mL
5 mM	1.3060 mL	6.5300 mL	13.0599 mL	65.2997 mL
10 mM	0.6530 mL	3.2650 mL	6.5300 mL	32.6499 mL
20 mM	0.3265 mL	1.6325 mL	3.2650 mL	16.3249 mL
50 mM	0.1306 mL	0.6530 mL	1.3060 mL	6.5300 mL
100 mM	0.0653 mL	0.3265 mL	0.6530 mL	3.2650 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc