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GW9508

🥰Excellent
Catalog No. T1781Cas No. 885101-89-3
Alias GW 9508

GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.

GW9508

GW9508

🥰Excellent
Purity: 99.19%
Catalog No. T1781Alias GW 9508Cas No. 885101-89-3
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$29In StockIn Stock
25 mg$48In StockIn Stock
50 mg$78In StockIn Stock
100 mg$143In StockIn Stock
200 mg$212In Stock-
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.19%
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Product Introduction

Bioactivity
Description
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
Targets&IC50
FFA1/GPR40:7.32(pEC50), GPR120:5.46(pEC50)
In vivo
In MIN6 cells, GW9508 stimulates insulin secretion in a dose-dependent manner and enhances insulin secretion mediated by KCl. In rat β-cells, GW9508 induces hyperpolarization and the opening of KATP channels. In HaCaT cells, GW9508 inhibits the expression of IL-11, IL-24, and IL-33 induced by TNF-α and IFN-γ. Additionally, in normal human epidermal keratinocytes, GW9508 suppresses the production of CCL5 and CXCL10.
SynonymsGW 9508
Chemical Properties
Molecular Weight347.41
FormulaC22H21NO3
Cas No.885101-89-3
SmilesO(C1=CC(CNC2=CC=C(CCC(O)=O)C=C2)=CC=C1)C3=CC=CC=C3
Relative Density.1.222 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 34.7 mg/mL (99.88 mM), Sonication is recommended.
DMSO: 150 mg/mL (431.77 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.51 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.8784 mL14.3922 mL28.7844 mL143.9222 mL
5 mM0.5757 mL2.8784 mL5.7569 mL28.7844 mL
10 mM0.2878 mL1.4392 mL2.8784 mL14.3922 mL
20 mM0.1439 mL0.7196 mL1.4392 mL7.1961 mL
50 mM0.0576 mL0.2878 mL0.5757 mL2.8784 mL
DMSO
1mg5mg10mg50mg
100 mM0.0288 mL0.1439 mL0.2878 mL1.4392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TNF-αPotassiumChannelPotassium ChannelKcsAKATPinsulinInhibitorinhibitIFN-γGW-9508GW9508GPR40(FFA1)GPR40GPR120glucose-sensitiveFree Fatty Acid ReceptorFFARFFA1CXCL10CCL5anti-inflammatoryanti-atherosclerotic
Related Tags: buy GW9508 | purchase GW9508 | GW9508 cost | order GW9508 | GW9508 chemical structure | GW9508 in vivo | GW9508 formula | GW9508 molecular weight
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