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Target / Pathway Focused

A target-focused library is a screening collection of compounds specifically tailored to modulate the function of a particular target or a protein family. These libraries not only reduce waste by eliminating compounds that are unlikely to bind to target proteins, but often lead to the increased potency and specificity of binders, as demonstrated for c-Src kinase. Compared to large and diverse screening libraries, using relatively small and targeted collections significantly improves the odds of finding potential drug candidates, thus further reduces the costs of drug discovery.

Kinase Inhibitor Library
L1600
A unique collection of 2840 kinase inhibitors regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Epigenetics Compound Library
L1200
Well-chosen 1090 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Mitochondria-Targeted Compound Library
L5300
A unique collection of 950 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
GPCR Compound Library
L1500
A unique collection of 2273 GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target identification and research;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Ion Channel Targeted Library
L2300
A unique collection of 1147 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Neurotransmitter Receptor Compound Library
L2610
A unique collection of 1660 neurotransmitter receptor compounds, can be used for HTS and HCS screening;
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TargetMol | Inhibitor Hot
Nuclear Receptor Compound Library
L1510
A unique collection of 631 nuclear receptor signaling targeted compounds for high throughput and high content screening;
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TargetMol | Inhibitor Hot
Wnt/Hedgehog/Notch Compound Library
L4300
A unique collection of 398 Wnt Hedgehog Notch signaling targeted compounds for high throughput and high content screening;
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TargetMol | Inhibitor Hot
Neuronal Signaling Compound Library
L2600
A unique collection of 2771 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
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TargetMol | Inhibitor Hot
FDA-Approved Kinase Inhibitor Library
L1610
A unique collection of 263 kinase inhibitors regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
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TargetMol | Inhibitor Hot
JAK-STAT Compound Library
L3700
A unique collection of 415 JAK STAT signaling targeted compounds for high throughput and high content screening;
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TargetMol | Citations Cited
Ubiquitination Compound Library
L8600
A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening;
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TargetMol | Citations Cited
Phosphatase Inhibitor Library
L9100
A collection of 127 phosphatase inhibitors with known activity;
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TargetMol | Citations Cited
Exosome Compound Library
L9420
76 exosome-related compounds that can be used for high-throughput and high-content screening.
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TGF-beta/Smad Compound Library
L4100
A unique collection of 184 TGF-beta Smad signaling targeted compounds for high throughput and high content screening;
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HIF-1 Signaling Pathway Compound Library
L8500
A unique collection of 2080 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;
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TargetMol | Inhibitor Hot
DNA Damage & Repair Compound Library
L3900
A unique collection of 1040 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
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TargetMol | Citations Cited
Cytokine Inhibitor Library
L3600
A unique collection of 815 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Pyroptosis Compound Library
L8720
1066 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
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TargetMol | Inhibitor Hot
Protease Inhibitor Library
L1100
A unique collection of 507 protease and proteasome inhibitors for research in chemical genomics, and drug screening;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Autophagy Compound Library
L3200
A unique collection of 1470 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs;
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Cell Cycle Compound Library
L8100
A unique collection of 945 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);
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TargetMol | Citations Cited
Serotonin Receptor-Targeted Compound Library
L2800
A unique collection of 424 compounds targeting serotonin receptors for high throughput screening and high content screening;
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Chemokine Inhibitor Library
L7600
A unique collection of 89 chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
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TargetMol | Citations Cited
MAPK Inhibitor Library
L1400
A unique collection of 500 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
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TargetMol | Citations Cited
Microtubule-Targeted Compound Library
L1110
A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS;
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Tyrosine Kinase Inhibitor Library
L2200
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
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Inhibitor Library
L2000
A unique collection of 9730 inhibitors for research in cell signaling, high throughput screening (HTS) and high content screening (HCS) for new drugs;
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TargetMol | Citations Cited
Adrenergic Receptor-Targeted Compound Library
L2700
A unique collection of 280 bioactive compounds specifically targeting adrenergic receptors, effective tool for screening new drugs or new target identification;
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TargetMol | Citations Cited
NF-κB Signaling Compound Library
L3800
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
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Potassium Channel Targeted Library
L7300
A unique collection of 215 potassium channel blockers and agonists for high throughput and high content screening;
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Angiogenesis related Compound Library
L4800
A unique collection of 2300 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS);
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AMPK-Targeted Compound Library
L1120
80 well-chosen unique AMPK-targeted small molecules;
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Ferroptosis Compound Library
L8700
A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study;
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Methylation Compound Library
L3510
128 methylation-related compounds that can be used for high-throughput and high-content screening.
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PI3K-AKT-mTOR Compound Library
L1300
A unique collection of 610 compounds targeting PI3K Akt mTOR signaling for research in PI3K Akt mTOR signaling, and drug discovery in diseases involved with PI3K Akt mTOR signaling;
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Cytoskeletal Signaling Pathway Compound Library
L1310
A unique collection of 759 cytoskeleton-related compounds, can be used for HTS and HCS;
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Endoplasmic Reticulum Stress Compound Library
L9700
A unique collection of 223 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
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Apoptosis Compound Library
L9000
A unique collection of 2394 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
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Calcium Channel Compound Library
L7200
A unique collection of 240 calcium channel blockers and agonists for high throughput and high content screening;
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Sodium Channel Targeted Library
L7400
A unique collection of 170 sodium channel blockers and agonists for high throughput and high content screening;
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Histamine & Melatonin Receptor-Targeted Compound Library
L3300
A unique collection of 188 compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS) for new drugs;
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Cuproptosis Compound Library
L8710
TargetMol’s Cuproptosis Compound Library is a collection of 400 compounds related to copper-dependent death that can be used to study its mechanism and related diseases.
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