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Anti-E-Selectin/CD62E Antibody-PE (5C686)
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Catalog No. TMAY-00641P
Anti-E-Selectin/CD62E Antibody-PE (5C686) is a PE-conjugated Rabbit antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody-PE (5C686) can be used in FCM.
Anti-E-Selectin/CD62E Antibody-PE (5C686)
Anti-E-Selectin/CD62E Antibody-PE (5C686)
🥰Excellent
Catalog No. TMAY-00641P
Anti-E-Selectin/CD62E Antibody-PE (5C686) is a PE-conjugated Rabbit antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody-PE (5C686) can be used in FCM.
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
| Description | Anti-E-Selectin/CD62E Antibody-PE (5C686) is a PE-conjugated Rabbit antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody-PE (5C686) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5C686 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD62E in HUVEC cells. HUVEC cells (Human umbilical vein endothelial cells) were treated with TNF-α (50 ng/ml, 18 hours). The cells were harvested and stained with PE Rabbit anti-Human CD62E. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human E-Selectin / CD62e (rh E-Selectin / CD62e; TMPY-01167; NP_000441.2; Met 1-Pro 556) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. Besides, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human E-Selectin / CD62e protein (TMPY-01167) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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