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CC-885

Name: CC-885
Brand: TargetMol
SKU: T14893
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14893Cas No. 1010100-07-8

CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.

CC-885

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Purity: 99.83%

Catalog No. T14893Cas No. 1010100-07-8

CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$322	In Stock	In Stock
50 mg	$483	In Stock	In Stock
100 mg	$723	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$142	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.

In vitro

CC-885 exhibits stronger antiproliferative effects than Lenalidomide and Pomalidomide across various cell types, including acute myeloblastic leukemia (AML) cell lines, THLE-2 human liver epithelial cells, and human peripheral blood mononuclear cells (PBMC), with IC50 values ranging from 10×-6-1 μM. The compound's efficacy was also assessed in 293T HEK cells engineered to express variants of GSPT1 that are either sensitive or resistant to CC-885. The study further explores the mechanism behind CC-885's cytotoxicity, particularly its dependency on cereblon-mediated degradation of GSPT1. By utilizing a GSPT1 mutant which maintains its functionality but lacks the cereblon binding affected by CC-885, the research distinguishes GSPT1's role from other potential targets. Notably, cells overexpressing the CC-885-resistant GSPT1 variant (GSPT1Δ(1–138)/(G575N)) were completely resistant to the compound's inhibitory effects on cell proliferation. In contrast, overexpressing a CC-885-sensitive variant (GSPT1Δ(1-138)) provided only partial protection against these effects, indicating the critical role of GSPT1 degradation in CC-885's mechanism of action. Similar outcomes were observed in AML cell lines[1].

Chemical Properties

Molecular Weight	440.88
Formula	C₂₂H₂₁ClN₄O₄
Cas No.	1010100-07-8
Smiles	O=C1N(CC=2C1=CC=C(CNC(NC3=CC(Cl)=C(C)C=C3)=O)C2)C4C(=O)NC(=O)CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 67.5 mg/mL (153.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2682 mL	11.3410 mL	22.6819 mL	113.4095 mL
5 mM	0.4536 mL	2.2682 mL	4.5364 mL	22.6819 mL
10 mM	0.2268 mL	1.1341 mL	2.2682 mL	11.3410 mL
20 mM	0.1134 mL	0.5670 mL	1.1341 mL	5.6705 mL
50 mM	0.0454 mL	0.2268 mL	0.4536 mL	2.2682 mL
100 mM	0.0227 mL	0.1134 mL	0.2268 mL	1.1341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc