Ardisianone, a compound with an alkylbenzoquinone structure, is isolated from extracts of Ardisia virens Kurz and Ardisia compressa tea. It exhibits potent anti-leukemic activity, particularly in HL-60 cells, where its IC50 values are 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. It is useful for acute myeloid leukemia (AML) research.

Ardisianone, when applied at 1-5 μM for 24-48 hours, induces apoptosis in HL-60 cells and exhibits potent cytotoxicity, with IC 50 values of 1.87 μM at 24 hours and 1.67 μM at 48 hours. At concentrations of 2-5 μM over 24 hours, it also shows pyroptosis-inducing activity in HL-60 cells. Furthermore, Ardisianone at 0.5-2 μM over 72 hours significantly enhances the expression of CD11b and CD68 in these cells and promotes differentiation into monocyte-like and macrophage-like morphologies. At 2 μM, Ardisianone demonstrates DNA damage-inducing activity in HL-60 cells.