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CDK7/9-IN-1
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Catalog No. T40353Cas No. 2747919-19-1
Alias CDK7/9-IN-1
CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9), targeting CDK7 with IC50 values of 0.0656 μM without pre-incubation and 0.00574 μM after 3 hours pre-incubation, and displaying inhibitory activity against CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation, making it valuable for cancer research.
CDK7/9-IN-1
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Catalog No. T40353Alias CDK7/9-IN-1Cas No. 2747919-19-1
CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9), targeting CDK7 with IC50 values of 0.0656 μM without pre-incubation and 0.00574 μM after 3 hours pre-incubation, and displaying inhibitory activity against CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation, making it valuable for cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $970 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
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| Description | CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9), targeting CDK7 with IC50 values of 0.0656 μM without pre-incubation and 0.00574 μM after 3 hours pre-incubation, and displaying inhibitory activity against CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation, making it valuable for cancer research. |
| Targets&IC50 | CDK7:5.74-65.6 nM (IC50), CDK9:2.14 μM (IC50) |
| In vitro | CDK7/9-IN-1 (example 8; 0.001-20 μM; 4 h) selectively inhibits CDK7, CDK9, and cMyc in HCT116 cells, with IC50 values of 0.0262 μM, 2.59 μM, and 0.0138 μM, respectively, for their targeted phospho-carboxyl terminal domains (Rbp2) (Ser5 for CDK7 and Ser2 for CDK9). At concentrations of 20 μM, 2 μM, and 0.2 μM for 1 hour, CDK7/9-IN-1 exhibits exceptional selectivity, inhibiting approximately 96% of CDK7 activity across a panel of 468 protein kinases[1]. |
| Synonyms | CDK7/9-IN-1 |
| Molecular Weight | 479.548 |
| Formula | C24H32F3N5O2 |
| Cas No. | 2747919-19-1 |
| Smiles | CC(C)c1cnc2c(NC3CCN(C[C@@H]4CN(CCO4)C(=O)C=C)CC3)cc(cn12)C(F)(F)F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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