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CDK7/9-IN-1

Catalog No. T40353 CAS 2747919-19-1

Synonyms: CDK7/9-IN-1

CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for such investigations.

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CDK7/9-IN-1, CAS 2747919-19-1

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5 mg	Inquiry	$ 970.00

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Description	CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for such investigations.
Targets&IC50	CDK7:5.74-65.6 nM (IC50), CDK9:2.14 μM (IC50)
In vitro	CDK7/9-IN-1 (example 8; 0.001-20 μM; 4 h) selectively inhibits CDK7, CDK9, and cMyc in HCT116 cells, displaying IC50 values of 0.0262 μM, 2.59 μM, and 0.0138 μM, respectively, for their targeted phospho-carboxyl terminal domains (Rbp2) (Ser5 for CDK7 and Ser2 for CDK9) and overall activity. Furthermore, when tested at concentrations of 20 μM, 2 μM, and 0.2 μM for 1 hour, CDK7/9-IN-1 demonstrates exceptional selectivity, inhibiting approximately 96% of CDK7 activity across a panel of 468 protein kinases[1].

Synonyms	CDK7/9-IN-1
Molecular Weight	479.548
Formula	C24H32F3N5O2
CAS No.	2747919-19-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Maria Carmen FERNANDEZ FIGUEROA, et al. Compounds useful for inhibiting cdk7. WO2021242602 A1.

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Keywords

CDK7/9-IN-1 2747919-19-1 CDK7/9IN1 CDK-7/9-IN-1 CDK7/9 IN 1 inhibitor inhibit

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