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9(E),11(E)-12-nitro Conjugated Linoleic Acid

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Catalog No. T37270Cas No. 1515620-30-0

9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma.

9(E),11(E)-12-nitro Conjugated Linoleic Acid

9(E),11(E)-12-nitro Conjugated Linoleic Acid

😃Good
Catalog No. T37270Cas No. 1515620-30-0
9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μg$13335 days35 days
100 μg$24635 days35 days
250 μg$56835 days35 days
500 μg$1,09035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma.
Chemical Properties
Molecular Weight325.449
FormulaC18H31NO4
Cas No.1515620-30-0
Relative Density.1.016 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 50 mg/mL (153.63 mM), Sonication is recommended.
DMF: 50 mg/mL (153.63 mM), Sonication is recommended.
DMSO: 50 mg/mL (153.63 mM), Sonication is recommended.
0.1 M Na2CO3: 1 mg/mL (3.07 mM), Sonication is recommended.
Solution Preparation Table
0.1 M Na2CO3/Ethanol/DMF/DMSO
1mg5mg10mg50mg
1 mM3.0727 mL15.3634 mL30.7268 mL153.6339 mL
Ethanol/DMF/DMSO
1mg5mg10mg50mg
5 mM0.6145 mL3.0727 mL6.1454 mL30.7268 mL
10 mM0.3073 mL1.5363 mL3.0727 mL15.3634 mL
20 mM0.1536 mL0.7682 mL1.5363 mL7.6817 mL
50 mM0.0615 mL0.3073 mL0.6145 mL3.0727 mL
100 mM0.0307 mL0.1536 mL0.3073 mL1.5363 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

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