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9(E),11(E)-12-nitro Conjugated Linoleic Acid

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Catalog No. T37270Cas No. 1515620-30-0

9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma.

9(E),11(E)-12-nitro Conjugated Linoleic Acid

9(E),11(E)-12-nitro Conjugated Linoleic Acid

😃Good
Catalog No. T37270Cas No. 1515620-30-0
9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma.
Pack SizePriceAvailabilityQuantity
50 μgTBD35 days
100 μgTBD35 days
250 μgTBD35 days
500 μgTBD35 days
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma.
Chemical Properties
Molecular Weight325.449
FormulaC18H31NO4
Cas No.1515620-30-0
Relative Density.1.016 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 50 mg/mL (153.63 mM), Sonication is recommended.
DMF: 50 mg/mL (153.63 mM), Sonication is recommended.
DMSO: 50 mg/mL (153.63 mM), Sonication is recommended.
0.1 M Na2CO3: 1 mg/mL (3.07 mM), Sonication is recommended.
Solution Preparation Table
0.1 M Na2CO3/Ethanol/DMF/DMSO
1mg5mg10mg50mg
1 mM3.0727 mL15.3634 mL30.7268 mL153.6339 mL
Ethanol/DMF/DMSO
1mg5mg10mg50mg
5 mM0.6145 mL3.0727 mL6.1454 mL30.7268 mL
10 mM0.3073 mL1.5363 mL3.0727 mL15.3634 mL
20 mM0.1536 mL0.7682 mL1.5363 mL7.6817 mL
50 mM0.0615 mL0.3073 mL0.6145 mL3.0727 mL
100 mM0.0307 mL0.1536 mL0.3073 mL1.5363 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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Keywords

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