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Eflornithine

Name: Eflornithine
Brand: TargetMol
SKU: T40811
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40811Cas No. 70052-12-9

Alias α-difluoromethylornithine, RMI71782, MDL71782, DFMO

Eflornithine (DFMO) is a selective and orally available ornithine decarboxylase inhibitor that delays hair overgrowth.Eflornithine is used in the study of African trypanosomiasis, malignant glioma, and sleeping sickness.

Eflornithine

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Purity: 99.84%

Catalog No. T40811Alias α-difluoromethylornithine, RMI71782, MDL71782, DFMOCas No. 70052-12-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$31	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Eflornithine (DFMO) is a selective and orally available ornithine decarboxylase inhibitor that delays hair overgrowth.Eflornithine is used in the study of African trypanosomiasis, malignant glioma, and sleeping sickness.
In vivo	Eflornithine is the only newly registered molecule for the treatment of human African trypanosomiasis in the past 50 years, mainly serving as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive facial hair, eflornithine 15% cream reduces hair growth more effectively than placebo, with 58% of eflornithine users showing improvement after 24 weeks compared to 34% for placebo[2]. The hair growth inhibitory effect is significantly enhanced when eflornithine cream is applied to mouse skin pretreated with microneedles[3]. In coarctation hypertensive rats, eflornithine treatment normalizes contractile responses to KCI and norepinephrine and acetylcholine-induced relaxations after 14 days[4].
Synonyms	α-difluoromethylornithine, RMI71782, MDL71782, DFMO

Chemical Properties

Molecular Weight	182.17
Formula	C₆H₁₂F₂N₂O₂
Cas No.	70052-12-9
Smiles	O=C(O)C(N)(CCCN)C(F)F

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (274.47 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.4894 mL	27.4469 mL	54.8938 mL	274.4689 mL
5 mM	1.0979 mL	5.4894 mL	10.9788 mL	54.8938 mL
10 mM	0.5489 mL	2.7447 mL	5.4894 mL	27.4469 mL
20 mM	0.2745 mL	1.3723 mL	2.7447 mL	13.7234 mL
50 mM	0.1098 mL	0.5489 mL	1.0979 mL	5.4894 mL
100 mM	0.0549 mL	0.2745 mL	0.5489 mL	2.7447 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc