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Chembridge-5861528

Name: Chembridge-5861528
Brand: TargetMol
SKU: T2711
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2711Cas No. 332117-28-9

Alias TCS 5861528

Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that inhibits AITC- and 4-HNE-induced calcium influx with IC50 values of 14.3 μM and 18.7 μM, respectively.

Chembridge-5861528

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Purity: 99.97%

Catalog No. T2711Alias TCS 5861528Cas No. 332117-28-9

Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that inhibits AITC- and 4-HNE-induced calcium influx with IC50 values of 14.3 μM and 18.7 μM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$278	In Stock	In Stock
200 mg	$397	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$38	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Color:White

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COA HNMR LCMS

Product Introduction

Chembridge-5861528 AI Summary

Chembridge-5861528 exhibits dual bioactivities on the TRPA1 channel, acting as an agonist by activating the mouse TRPA1 channel with an EC50 of 2500000.0 nM and as an antagonist by inhibiting both 4-hydroxy-2-nonenal-induced response (IC50 = 18700.0 nM) and allyl isothiocyanate-induced intracellular calcium influx (IC50 = 14300.0 nM) on the human TRPA1 channel. Additionally, it demonstrates antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 µM after 48 hours, with an inhibition rate of 24.32%, and of VERO-6 cells under the same conditions, but with a lower inhibition rate of 0.19%. The compound also inhibits the SARS-CoV-2 3CL-Pro protease by 18.56% at a concentration of 20 µM, indicating potential bioactivity against viral replication processes. Furthermore, Chembridge-5861528 serves as an inhibitor of the human HDAC6 enzyme, with 18.15% inhibition observed in an enzymatic assay using a commercial peptide substrate, and 0.26% inhibition using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that inhibits AITC- and 4-HNE-induced calcium influx with IC50 values of 14.3 μM and 18.7 μM, respectively.
Targets&IC50	Ca2+ influx (AITC-evoked):14.3μM, Ca2+ influx (4-HNE-evoked):18.7 μM
Synonyms	TCS 5861528

Chemical Properties

Molecular Weight	369.42
Formula	C₁₉H₂₃N₅O₃
Cas No.	332117-28-9
Smiles	CCC(C)c1ccc(NC(=O)Cn2cnc3n(C)c(=O)n(C)c(=O)c23)cc1
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (135.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7069 mL	13.5347 mL	27.0695 mL	135.3473 mL
5 mM	0.5414 mL	2.7069 mL	5.4139 mL	27.0695 mL
10 mM	0.2707 mL	1.3535 mL	2.7069 mL	13.5347 mL
20 mM	0.1353 mL	0.6767 mL	1.3535 mL	6.7674 mL
50 mM	0.0541 mL	0.2707 mL	0.5414 mL	2.7069 mL
100 mM	0.0271 mL	0.1353 mL	0.2707 mL	1.3535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc