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ZYZ-488

Name: ZYZ-488
Brand: TargetMol
SKU: T13417
Rating: 4.5 (1 reviews)

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Catalog No. T13417Cas No. 1470302-79-4

Alias ZYZ488

ZYZ-488 is an Apoptotic Protease-Activating Factor 1 (Apaf-1) inhibitor that inhibits the activation of procaspase-9 and procaspase-3. It can be used to study cardiovascular diseases.

ZYZ-488

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Purity: 99.04%

Catalog No. T13417Alias ZYZ488Cas No. 1470302-79-4

ZYZ-488 is an Apoptotic Protease-Activating Factor 1 (Apaf-1) inhibitor that inhibits the activation of procaspase-9 and procaspase-3. It can be used to study cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$297	6-8 weeks	6-8 weeks
25 mg	$987	6-8 weeks	6-8 weeks
50 mg	$1,360	6-8 weeks	6-8 weeks
100 mg	$1,860	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$365	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.04%

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COA

Product Introduction

Bioactivity

Description	ZYZ-488 is an Apoptotic Protease-Activating Factor 1 (Apaf-1) inhibitor that inhibits the activation of procaspase-9 and procaspase-3. It can be used to study cardiovascular diseases.
In vitro	ZYZ-488 is a novel inhibitor of apoptotic protease activator 1 (Apaf-1). The main mechanism is that ZYZ-488 binds directly to Apaf-1, thus blocking the recruitment of procaspase-9 by Apaf-1. [1]
In vivo	Intramuscular injection of ZYZ-488 (33.9 mg/kg or 67.8 mg/kg) in mice reduced the MI-induced increase in left ventricular volume and reduced the thickness of the ventricular wall. ZYZ-488 preserves cardiac function in a dose-dependent manner. [1] [2]
Synonyms	ZYZ488

Chemical Properties

Molecular Weight	487.46
Formula	C₂₀H₂₉N₃O₁₁
Cas No.	1470302-79-4
Smiles	O(C1=C(OC)C=C(C(OCCCCNC(=N)N)=O)C=C1OC)[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O
Relative Density.	1.57 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (164.12 mM), Sonication is recommended.

DMSO: 180 mg/mL (369.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0515 mL	10.2573 mL	20.5145 mL	102.5725 mL
5 mM	0.4103 mL	2.0515 mL	4.1029 mL	20.5145 mL
10 mM	0.2051 mL	1.0257 mL	2.0515 mL	10.2573 mL
20 mM	0.1026 mL	0.5129 mL	1.0257 mL	5.1286 mL
50 mM	0.0410 mL	0.2051 mL	0.4103 mL	2.0515 mL
100 mM	0.0205 mL	0.1026 mL	0.2051 mL	1.0257 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc