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D4-abiraterone

Name: D4-abiraterone
Brand: TargetMol
SKU: T10946
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10946Cas No. 154229-21-7

Alias Δ4-Abiraterone, Delta4-Abiraterone, CB-7627, CB7627, Abiraterone D4A metabolite

D4-abiraterone is the active metabolite of abiraterone produced by 3β-HSD and is further metabolised by SRD5A.Δ4-Abiraterone is an inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.

D4-abiraterone

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Purity: 99.8%

Catalog No. T10946Alias Δ4-Abiraterone, Delta4-Abiraterone, CB-7627, CB7627, Abiraterone D4A metaboliteCas No. 154229-21-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	-	In Stock
5 mg	$89	-	In Stock
10 mg	$163	-	In Stock
25 mg	$363	-	In Stock
50 mg	$538	-	In Stock
100 mg	$766	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.8%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	D4-abiraterone is the active metabolite of abiraterone produced by 3β-HSD and is further metabolised by SRD5A.Δ4-Abiraterone is an inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.
Targets&IC50	Androgen receptor:5.3-7.9 nM
In vitro	D4-abiraterone (10 μM) nearly fully blocks AD conversion to 5α-androgens. D4-abiraterone binds AR more strongly (IC₅₀ = 5.3-7.9 nM) than abiraterone (IC₅₀ = 418-500+ nM), and more effectively suppresses AR target genes like PSA[1].
In vivo	In LNCaP and VCaP mouse tumors, D4-abiraterone was 10× stronger than abiraterone. At 0.1 μM, D4-abiraterone matched 1 μM abiraterone in blocking AD formation and delayed tumor growth within 48 h[1].
Synonyms	Δ4-Abiraterone, Delta4-Abiraterone, CB-7627, CB7627, Abiraterone D4A metabolite

Chemical Properties

Molecular Weight	347.49
Formula	C₂₄H₂₉NO
Cas No.	154229-21-7
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC=C2C=5C=CC=NC5)[H]
Relative Density.	1.14 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (115.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8778 mL	14.3889 mL	28.7778 mL	143.8890 mL
5 mM	0.5756 mL	2.8778 mL	5.7556 mL	28.7778 mL
10 mM	0.2878 mL	1.4389 mL	2.8778 mL	14.3889 mL
20 mM	0.1439 mL	0.7194 mL	1.4389 mL	7.1945 mL
50 mM	0.0576 mL	0.2878 mL	0.5756 mL	2.8778 mL
100 mM	0.0288 mL	0.1439 mL	0.2878 mL	1.4389 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc