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D4-abiraterone

Name: D4-abiraterone
Brand: TargetMol
SKU: T10946
Rating: 4.5 (1 reviews)

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Catalog No. T10946Cas No. 154229-21-7

Alias Δ4-Abiraterone, Delta4-Abiraterone, CB-7627, CB7627, Abiraterone D4A metabolite

D4-abiraterone is the active metabolite of abiraterone produced by 3β-HSD and is further metabolised by SRD5A.Δ4-Abiraterone is an inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.

D4-abiraterone

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Purity: 99.75%

Catalog No. T10946Alias Δ4-Abiraterone, Delta4-Abiraterone, CB-7627, CB7627, Abiraterone D4A metaboliteCas No. 154229-21-7

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Purity:99.75%

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COA

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Product Introduction

Bioactivity

Description	D4-abiraterone is the active metabolite of abiraterone produced by 3β-HSD and is further metabolised by SRD5A.Δ4-Abiraterone is an inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.
Targets&IC50	Androgen receptor:5.3-7.9 nM
In vitro	D4-abiraterone (10 μM) nearly fully blocks AD conversion to 5α-androgens. D4-abiraterone binds AR more strongly (IC₅₀ = 5.3-7.9 nM) than abiraterone (IC₅₀ = 418-500+ nM), and more effectively suppresses AR target genes like PSA[1].
In vivo	In LNCaP and VCaP mouse tumors, D4-abiraterone was 10× stronger than abiraterone. At 0.1 μM, D4-abiraterone matched 1 μM abiraterone in blocking AD formation and delayed tumor growth within 48 h[1].
Alias	Δ4-Abiraterone, Delta4-Abiraterone, CB-7627, CB7627, Abiraterone D4A metabolite

Chemical Properties

Molecular Weight	347.49
Formula	C₂₄H₂₉NO
Cas No.	154229-21-7
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC=C2C=5C=CC=NC5)[H]
Relative Density.	1.14 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (115.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8778 mL	14.3889 mL	28.7778 mL	143.8890 mL
5 mM	0.5756 mL	2.8778 mL	5.7556 mL	28.7778 mL
10 mM	0.2878 mL	1.4389 mL	2.8778 mL	14.3889 mL
20 mM	0.1439 mL	0.7194 mL	1.4389 mL	7.1945 mL
50 mM	0.0576 mL	0.2878 mL	0.5756 mL	2.8778 mL
100 mM	0.0288 mL	0.1439 mL	0.2878 mL	1.4389 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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