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Anti-CD163 Antibody (2R634)
(Synonyms: sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163) Copy Product Info
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Synonyms: sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163
Catalog No. TMAH-00173 Copy Product Info
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Anti-CD163 Antibody (2R634) is an antibody targeting CD163. Anti-CD163 Antibody (2R634) can be used in ELISA,IHC.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CD163 Antibody (2R634) is an antibody targeting CD163. Anti-CD163 Antibody (2R634) can be used in ELISA,IHC. |
| Synonyms | sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163 |
| Ig Type | hIgG1 |
| Clone | 2R634 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Soluble CD163]: Secreted.; Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells. |
| Tissue Specificity | Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed a |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD163 Protein |
| Antigen Species | Human |
| Gene Name | CD163 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cardiovascular, Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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