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Anti-CD163 Antibody (2R634)
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Catalog No. TMAH-00173
Alias sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163
Anti-CD163 Antibody (2R634) is an antibody targeting CD163. Anti-CD163 Antibody (2R634) can be used in ELISA, IHC.
Anti-CD163 Antibody (2R634)
Anti-CD163 Antibody (2R634)
😃Good
Catalog No. TMAH-00173Alias sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163
Anti-CD163 Antibody (2R634) is an antibody targeting CD163. Anti-CD163 Antibody (2R634) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, IHC Reactivity: Human |
| Alias | sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163 |
| Ig Type | hIgG1 |
| Clone | 2R634 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00173 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Soluble CD163]: Secreted.; Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD163 Protein |
| Antigen Species | Human |
| Gene ID | 9332 |
| Uniprot ID | |
| Biology Area | Cardiovascular, Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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