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Handle region peptide, rat acetate
🥰Excellent
Catalog No. TP1761L
Alias Handle region peptide, rat acetate(749227-53-0 free base)
Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
Handle region peptide, rat acetate
🥰Excellent
Purity: 99.01%
Catalog No. TP1761LAlias Handle region peptide, rat acetate(749227-53-0 free base)
Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $133 | In Stock | In Stock | |
| 5 mg | $302 | In Stock | In Stock | |
| 10 mg | $453 | In Stock | In Stock | |
| 25 mg | $747 | In Stock | In Stock | |
| 50 mg | $1,050 | In Stock | In Stock | |
| 100 mg | $1,420 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.01%
Appearance:solid
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye. |
| In vitro | Handle region peptide, rat is a (pro)renin receptor antagonist. Handle region peptide, rat (1 μM) reduces the ratio of active to total ERK1/2. Handle region peptide, rat (0.1-1 μM) reduces TGF-β1 mRNA level, and inhibits the mesangial cells proliferation in a dose-dependent manner. Handle region peptide, rat (0.01-1 μM) increases the MMP-2 activity[1]. |
| In vivo | Handle region peptide, rat (0.1 mg/kg) suppresses leukocyte adhesion in the endotoxin-induced uveitis (EIU) retina, and decreases the leukocyte counts in rats. Handle region peptide, rat (0.1 mg/kg) lowers the protein concentration in EIU rats induced by LPS, and reduces the mRNA expression and the protein levels of inflammatory mediators such as ICAM-1, CCL2/MCP-1, and IL-6 in rats[2]. |
| Synonyms | Handle region peptide, rat acetate(749227-53-0 free base) |
| Molecular Weight | 1244.61 |
| Formula | C56H105N15O14S |
| Smiles | CC(C)[C@@H](C(O)=O)NC([C@H](CO)NC([C@H]1N(C([C@H](CCSC)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O.CC(O)=O |
| Relative Density. | no data available |
| Sequence | H-DL-Arg-DL-xiIle-DL-Leu-DL-Leu-DL-Lys-DL-Lys-DL-Met-DL-Pro-DL-Ser-DL-Val-OH.CH3CO2H |
| Sequence Short | RXLLKKMPSV |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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