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Handle region peptide, rat acetate

🥰Excellent
Catalog No. TP1761L
Alias Handle region peptide, rat acetate(749227-53-0 free base)

Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.

Handle region peptide, rat acetate
Other Forms of Handle region peptide, rat acetate:
Handle region peptide, ratTP1761749227-53-0
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Handle region peptide, rat acetate

🥰Excellent
Purity: 99.01%
Catalog No. TP1761LAlias Handle region peptide, rat acetate(749227-53-0 free base)
Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$133In StockIn Stock
5 mg$302In StockIn Stock
10 mg$453In StockIn Stock
25 mg$747In StockIn Stock
50 mg$1,050In StockIn Stock
100 mg$1,420In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.01%
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COA MS HPLC

Product Introduction

Bioactivity
Description
Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
In vitro
Handle region peptide, rat is a (pro)renin receptor antagonist. Handle region peptide, rat (1 μM) reduces the ratio of active to total ERK1/2. Handle region peptide, rat (0.1-1 μM) reduces TGF-β1 mRNA level, and inhibits the mesangial cells proliferation in a dose-dependent manner. Handle region peptide, rat (0.01-1 μM) increases the MMP-2 activity[1].
In vivo
Handle region peptide, rat (0.1 mg/kg) suppresses leukocyte adhesion in the endotoxin-induced uveitis (EIU) retina, and decreases the leukocyte counts in rats. Handle region peptide, rat (0.1 mg/kg) lowers the protein concentration in EIU rats induced by LPS, and reduces the mRNA expression and the protein levels of inflammatory mediators such as ICAM-1, CCL2/MCP-1, and IL-6 in rats[2].
SynonymsHandle region peptide, rat acetate(749227-53-0 free base)
Chemical Properties
Molecular Weight1244.61
FormulaC56H105N15O14S
SmilesCC(C)[C@@H](C(O)=O)NC([C@H](CO)NC([C@H]1N(C([C@H](CCSC)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O.CC(O)=O
Relative Density.no data available
SequenceH-DL-Arg-DL-xiIle-DL-Leu-DL-Leu-DL-Lys-DL-Lys-DL-Met-DL-Pro-DL-Ser-DL-Val-OH.CH3CO2H
Sequence ShortRXLLKKMPSV
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: Insoluble
H2O: 10 mM, Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.8035 mL4.0173 mL8.0346 mL40.1732 mL
5 mM0.1607 mL0.8035 mL1.6069 mL8.0346 mL
10 mM0.0803 mL0.4017 mL0.8035 mL4.0173 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

Prorenin receptorHandle region peptide, rat acetateHandle region peptide, rat Acetate
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