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Anti-CTLA-4 Antibody (8I311)

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Catalog No. TMAY-01710

Anti-CTLA-4 Antibody (8I311) is a Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody (8I311) can be used in ELISA,ELISA(Cap).

Anti-CTLA-4 Antibody (8I311)

Anti-CTLA-4 Antibody (8I311)

😃Good
Catalog No. TMAY-01710
Anti-CTLA-4 Antibody (8I311) is a Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody (8I311) can be used in ELISA,ELISA(Cap).
Pack SizePriceAvailabilityQuantity
20 μL$69 7-10 days
100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-CTLA-4 Antibody (8I311) is a Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody (8I311) can be used in ELISA,ELISA(Cap).
Ig Type
Monoclonal Mouse IgG2b
Clone
8I311
Reactivity
Human
Application
ELISA,ELISA(Cap)
Recommended Dose
ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CTLA-4 / CD152 (rh CTLA-4 / CD152; TMPY-04348; NP_005205.2; Met1-Phe162). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundCytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsCTLA4 / CD152 Immune Checkpoint ProteinsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Biotin
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human CTLA-4 / CD152 protein (TMPY-04348)
Antigen Species
Human
Biology Area
ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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