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Anti-CTLA-4 Antibody (8I311) is a Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody (8I311) can be used in ELISA,ELISA(Cap).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $69 | 7-10 days | |
100 μL | $198 | 7-10 days |
Description | Anti-CTLA-4 Antibody (8I311) is a Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody (8I311) can be used in ELISA,ELISA(Cap). |
Ig Type | Monoclonal Mouse IgG2b |
Clone | 8I311 |
Reactivity | Human |
Application | ELISA,ELISA(Cap) |
Recommended Dose | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CTLA-4 / CD152 (rh CTLA-4 / CD152; TMPY-04348; NP_005205.2; Met1-Phe162). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsCTLA4 / CD152 Immune Checkpoint ProteinsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
Conjucates | Unconjugated |
Others Formats | Biotin |
Antibody Types Available | 2 |
Immunogen | Recombinant Human CTLA-4 / CD152 protein (TMPY-04348) |
Antigen Species | Human |
Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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