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Micronomicin sulfate

Name: Micronomicin sulfate
Brand: TargetMol
SKU: T41294
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41294Cas No. 66803-19-8

Alias Sagamicin sulfate, Gentamicin C2b sulfate, Antibiotic XK-62-2 sulfate

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic with antimicrobial activity that inhibits neuraminidase N1 of influenza A virus.

Micronomicin sulfate

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Catalog No. T41294Alias Sagamicin sulfate, Gentamicin C2b sulfate, Antibiotic XK-62-2 sulfateCas No. 66803-19-8

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic with antimicrobial activity that inhibits neuraminidase N1 of influenza A virus.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$29	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic with antimicrobial activity that inhibits neuraminidase N1 of influenza A virus.
Targets&IC50	Escherichia coli St.M. 589:0.75 μg/ml (MIC), R5/W677:0.03 μg/ml (MIC), F 14-BK:0.03 μg/ml (MIC), Baker 2:0.3 μg/ml (MIC), Staphylococcus aureus FDA 209 P:0.01 μg/ml (MIC)
In vitro	Micronomicin sulfate exhibited significant antibacterial activity with a MIC of 0.01 μg/ml against Staphylococcus aureus FDA 209 P and other strains, and a MIC of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml against Escherichia coli St.M. 589, Baker 2, F 14-BK and R5/W677, respectively.In addition, it was found to be effective against Pseudomonas aeruginosa and Klebsiella pneumoniae strains with a MIC range of 0.03-17.5 μg/ml.[1]
In vivo	Micronomicin sulfate has shown strong activity against a wide range of bacterial infections in mice, with an acute LD50 (lethal dose) of 93 mg/kg administered intravenously.[1] In subacute toxicity studies, intravenous injections, 4-100 mg/kg Micronomicin sulfate, for 30 consecutive days were used in the test. At a dose of 100 mg/kg, 10 of the Wistar rats (out of a total of 30) died, exhibiting renal dysfunction and ataxia. Renal tissue lesions occurred mainly at doses of 25 mg/kg and above. [3]
Synonyms	Sagamicin sulfate, Gentamicin C2b sulfate, Antibiotic XK-62-2 sulfate

Chemical Properties

Molecular Weight	561.65
Formula	C₂₀H₄₁N₅O₇ xH₂O₄S
Cas No.	66803-19-8
Smiles	S(=O)(=O)(O)O.O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CNC)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3 xH2SO4

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30.00 mg/mL (53.41 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7805 mL	8.9023 mL	17.8047 mL	89.0234 mL
5 mM	0.3561 mL	1.7805 mL	3.5609 mL	17.8047 mL
10 mM	0.1780 mL	0.8902 mL	1.7805 mL	8.9023 mL
20 mM	0.0890 mL	0.4451 mL	0.8902 mL	4.4512 mL
50 mM	0.0356 mL	0.1780 mL	0.3561 mL	1.7805 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc