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GENZ-882706
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Catalog No. T11390Cas No. 2070864-35-4
Alias RA03546849
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor.
GENZ-882706
Copy Product Info😃Good
Catalog No. T11390Alias RA03546849Cas No. 2070864-35-4
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $3,120 | 3-6 months | 3-6 months | |
| 50 mg | $3,880 | 3-6 months | 3-6 months | |
| 100 mg | $5,000 | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor. |
| In vitro | Genz-882706 enhances proliferative activity in unstimulated cells 48 hours post-treatment. |
| In vivo | Daily administration of Genz-882706 markedly attenuates experimental autoimmune encephalomyelitis (EAE) severity. In EAE-affected mice, Genz-882706 significantly lowers MCP-1, IL-6, IL-1β, and IP-10 levels in spinal cord homogenates, contrasting sharply with those treated with a vehicle. Conversely, TNF-α levels in the spinal cord notably increase following Genz-882706 treatment compared to the vehicle group. Furthermore, Genz-882706 administrations, at both 30 mg/kg and 100 mg/kg dosages, substantially decrease the population of microglia and monocytes/macrophages in the brain and spinal cord, standing out from vehicle and LPS controls. Additionally, Genz-882706 modestly diminishes CD80 expression on monocytes/macrophages within the brain. |
| Synonyms | RA03546849 |
| Molecular Weight | 455.51 |
| Formula | C26H25N5O3 |
| Cas No. | 2070864-35-4 |
| Smiles | C(N1C=2C(=CC(C#CC(C)(C)N)=CN2)N=C1)C=3C=C4C(=CC3)O[C@H](CO4)C=5C=CC(OC)=NC5 |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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